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PPI Inhibitor Library

Catalog No. L9400
  Library Compound List   Excel SDF

Protein-protein interaction (PPI) inhibitors represent a vast class of therapeutic targets both intracellularly and extracellularly for a broad range of diseases, for instance cancer and HIV. The human interactome has been estimated to cover ~400,000 protein–protein interactions, making PPIs central to many biological processes, including enzymatic activity, assembly of protein complexes and subcellular localisation. However, PPIs are considered difficult to target. As a part of disease biological processes are often dysregulated, therefore PPIs have become an attractive target for therapy.

TargetMol’s PPI Inhibitor Library, a focused collection of 490 PPI-related compounds, can be used for research on protein-protein interaction.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Compound Libraries | TargetMol
Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
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Product Description

  • A unique collection of 490 PPI-related compounds for drug screening;
  • Targets include PD-1/PD-L1, Bcl-2, BET bromodomain, BRD4 bromodomain, etc.
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files
Request Library Compound List (L9400)

Publications Cited TargetMol Libraries

1. Cells. 2022, 11(18): 2839. 2. Biomolecules. 2023, 13(10): 1438. 3. Animal Cells and Systems. 2023, 27(1): 394-402. 4. Cell Stem Cell. 2022 Apr 29(4) 545–558. 5. Science Bulletin. 2022. 6. Science Translational Medicine. 2022, 14(656): eabn3231. 7. Science Advances. 2023, 9(9): eade3760. 8. Nature. 2020, 582: 289-293. 9. Nature Biotechnology. 2021, 39(11): 1444-1452.
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Library Composition

Epigenetic Reader Domain (111)
Apoptosis (78)
BCL (72)
Autophagy (38)
Nrf2 (34)
p53 (25)
Mdm2 (23)
HIV Protease (23)
E1/E2/E3 Enzyme (22)
Histone Methyltransferase (16)
Caspase (15)
PD-1/PD-L1 (14)
IAP (13)
NF-κB (12)
Ferroptosis (11)
Endogenous Metabolite (11)
RIP kinase (10)
Ras (9)
Wnt/beta-catenin (9)
DNA/RNA Synthesis (9)
PARP (8)
Histone Acetyltransferase (8)
Microtubule Associated (7)
p38 MAPK (7)
c-Myc (6)
COX (6)
STAT (6)
Sirtuin (6)
Akt (5)
TNF (5)
Antibacterial (5)
Parasite (5)
CDK (5)
Raf (5)
Rho (5)
IL Receptor (4)
Integrin (4)
JNK (4)
ERK (4)
PROTACs (4)
Dehydrogenase (4)
Ligand for E3 Ligase (4)
NMDAR (3)
Reactive Oxygen Species (3)
mTOR (3)
Sodium Channel (3)
Mitophagy (3)
PPAR (3)
Ligands for Target Protein for PROTAC (3)
PKC (3)
PI3K (3)
HIF/HIF Prolyl-Hydroxylase (3)
HSP (3)
PERK (3)
P-gp (3)
YAP (3)
HIF (3)
CXCR (3)
Carboxypeptidase (2)
Estrogen/progestogen Receptor (2)
Dopamine Receptor (2)
DNA-PK (2)
DNA Alkylator/Crosslinker (2)
PDE (2)
Phosphatase (2)
PLK (2)
Calcium Channel (2)
GABA Receptor (2)
Reverse Transcriptase (2)
Aryl Hydrocarbon Receptor (2)
Antioxidant (2)
Antifungal (2)
Src (2)
Antibiotic (2)
TLR (2)
Virus Protease (2)
NEDD8 (2)
5-HT Receptor (2)
Influenza Virus (2)
HDAC (2)
GSK-3 (2)
Lipoxygenase (2)
iGluR (2)
Integrase (2)
GTPase (2)
JAK (2)
IFNAR (2)
IκB/IKK (2)
IGF-1R (1)
ATPase (1)
Retinoid Receptor (1)
SARS-CoV (1)
ATTECs (1)
Beta Amyloid (1)
RAAS (1)
Proton pump (1)
Prostaglandin Receptor (1)
ROS (1)
Liver X Receptor (1)
Serine/threonin kinase (1)
Topoisomerase (1)
AhR (1)
Hedgehog/Smoothened (1)
VEGFR (1)
UGT (1)
Tyrosinase (1)
transporter (1)
Androgen Receptor (1)
Serotonin Transporter (1)
Thrombin (1)
TGF-beta/Smad (1)
STING (1)
HCV Protease (1)
HMG-CoA Reductase (1)
Smo (1)
GPCR19 (1)
Anti-infection (1)
CCR (1)
Potassium Channel (1)
Neurokinin receptor (1)
Gamma-secretase (1)
Mitochondrial Metabolism (1)
FXR (1)
MLK (1)
MMP (1)
MNK (1)
Molecular Glues (1)
Monoamine Oxidase (1)
Monoamine Transporter (1)
FAK (1)
MyD88 (1)
Myosin (1)
NADPH (1)
Glucokinase (1)
Neurotensin Receptor (1)
MAO (1)
DNA (1)
Chloride channel (1)
Glutathione Peroxidase (1)
Cysteine Protease (1)
PDK (1)
Interleukin (1)
Discoidin Domain Receptor (DDR) (1)
DNA Methyltransferase (1)
AChE (1)
Histamine Receptor (1)
GluR (1)
Ephrin Receptor (1)
NPC1L1 (1)
NO Synthase (1)
Estrogen Receptor/ERR (1)
P450 (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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