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NSC756093

Name: NSC756093
Brand: TargetMol
SKU: T24557
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24557Cas No. 1629908-92-4

Alias NSC-756093, NSC 756093

NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies.

NSC756093

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Purity: 99.92%

Catalog No. T24557Alias NSC-756093, NSC 756093Cas No. 1629908-92-4

NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
5 mg	$93	In Stock	In Stock
10 mg	$159	In Stock	In Stock
25 mg	$347	In Stock	In Stock
50 mg	$516	In Stock	In Stock
100 mg	$736	In Stock	In Stock
500 mg	$1,480	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$119	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

NSC756093 AI Summary

NSC756093 inhibits the interaction between GBP1 and PIM1 at a concentration of 100 nM, as determined by SPR analysis, resulting in a 65.0% inhibition. It exhibits synergistic antiproliferative activity against human SCC25 cells, reducing cell viability and colony formation units when preincubated at varying concentrations followed by irradiation with different doses of ionizing radiation. The compound also induces cell cycle arrest at the G2/M phase and promotes apoptosis in both SCC25 and FADU cells, enhancing its bioactivity in inhibiting cell growth and promoting cell death. Additionally, NSC756093 shows inhibition of cell migration in both cell lines when combined with irradiation and demonstrates selectivity towards FADU cells based on colony formation unit reduction and cell viability, while also exhibiting varying effects on SCC25 cells in the presence of ionizing radiation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies.
Synonyms	NSC-756093, NSC 756093

Chemical Properties

Molecular Weight	337.37
Formula	C₂₀H₁₉NO₄
Cas No.	1629908-92-4
Smiles	COc1ccc2C(C3=C(COC3=O)N(CCO)c2c1)c1ccccc1
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (163.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9641 mL	14.8205 mL	29.6410 mL	148.2052 mL
5 mM	0.5928 mL	2.9641 mL	5.9282 mL	29.6410 mL
10 mM	0.2964 mL	1.4821 mL	2.9641 mL	14.8205 mL
20 mM	0.1482 mL	0.7410 mL	1.4821 mL	7.4103 mL
50 mM	0.0593 mL	0.2964 mL	0.5928 mL	2.9641 mL
100 mM	0.0296 mL	0.1482 mL	0.2964 mL	1.4821 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc