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3-Nitropropanoic acid

Name: 3-Nitropropanoic acid
Brand: TargetMol
SKU: T3009
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3009Cas No. 504-88-1

Alias β-Nitropropionic acid, Bovinocidin, 3-NP acid, 3-NP

3-Nitropropanoic acid (Bovinocidin) is an irreversible inhibitor of succinate dehydrogenase.

3-Nitropropanoic acid

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Purity: 99.94%

Catalog No. T3009Alias β-Nitropropionic acid, Bovinocidin, 3-NP acid, 3-NPCas No. 504-88-1

3-Nitropropanoic acid (Bovinocidin) is an irreversible inhibitor of succinate dehydrogenase.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$31	In Stock	In Stock
100 mg	$41	In Stock	In Stock
200 mg	$50	In Stock	In Stock
500 mg	$67	In Stock	In Stock
1 g	$95	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

3-Nitropropanoic acid AI Summary

3-Nitropropanoic acid exhibits significant bioactivity across multiple domains, primarily as an inhibitor of isocitrate lyase (ICL) in various pathogenic microorganisms. Specifically, it demonstrates inhibitory effects against Candida albicans ICL with IC50 values ranging from 6,000.0 nM to 50,700.0 nM and antifungal activity with an IC50 value of 845,000.0 nM against Candida albicans ATCC 10231. In addition, it shows antimycobacterial activity against Mycobacterium tuberculosis H37Ra with a minimum inhibitory concentration (MIC) of 3,300.0 nM and also inhibits Mycobacterium tuberculosis ICL with varying degrees of inhibition, reporting an IC50 value of 11,600.0 nM. The compound targets other pathways as well, including modulation of various splicing activities, inhibition of the Menin-MLL interaction in leukemia, Bloom's syndrome helicase (BLM), and several other targets. While it also affects Magnaporthe grisea ICL with notable IC50 values, its cytotoxicity against mammalian cells and potential activity against SARS-CoV-2 suggest broader bioactivity profiles..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	3-Nitropropanoic acid (Bovinocidin) is an irreversible inhibitor of succinate dehydrogenase.
Synonyms	β-Nitropropionic acid, Bovinocidin, 3-NP acid, 3-NP

Chemical Properties

Molecular Weight	119.08
Formula	C₃H₅NO₄
Cas No.	504-88-1
Smiles	OC(=O)CC[N+]([O-])=O
Relative Density.	1.393g/cm3

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 247.5 mg/mL (2078.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (33.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	8.3977 mL	41.9886 mL	83.9772 mL	419.8858 mL
5 mM	1.6795 mL	8.3977 mL	16.7954 mL	83.9772 mL
10 mM	0.8398 mL	4.1989 mL	8.3977 mL	41.9886 mL
20 mM	0.4199 mL	2.0994 mL	4.1989 mL	20.9943 mL
50 mM	0.1680 mL	0.8398 mL	1.6795 mL	8.3977 mL
100 mM	0.0840 mL	0.4199 mL	0.8398 mL	4.1989 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc