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L-Carnitine

Name: L-Carnitine
Brand: TargetMol
SKU: T0846
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0846Cas No. 541-15-1

Alias Levocarnitine, L(-)-Carnitine

L-Carnitine (L(-)-Carnitine) is an amino acid derivative. L-Carnitine facilitates long-chain fatty acid entry into mitochondria, delivering substrate for oxidation and subsequent energy production. Fatty acids are utilized as an energy substrate in all tissues except the brain.

L-Carnitine

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Purity: 99.94%

Catalog No. T0846Alias Levocarnitine, L(-)-CarnitineCas No. 541-15-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$44	In Stock	In Stock
1 g	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.94%

Color:White

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COA HNMR LCMS

Product Introduction

L-Carnitine AI Summary

L-Carnitine exhibits a wide array of bioactivities and possesses significant potential in various biological systems. It is known for its effects on carnitine acyltransferases and carnitine palmitoyltransferases, showing specific kinetic constants and inhibitory effects in animal models and neonatal rat cardiac myocytes. The compound also demonstrates binding affinity to bovine serum albumin, particularly in the presence of Fe3+, and exhibits dose-dependent cytotoxicity against human HL60 and K562 cells. Furthermore, L-Carnitine shows permeability of 1.3 x 10^-6 cm/s at pH 6.5 and an oral bioavailability of 10.0% in humans. In terms of enzyme interaction, it is a potent inhibitor of AmpC Beta-Lactamase, induces genotoxicity and DNA re-replication, inhibits ELG1-dependent DNA repair, and acts against malaria by targeting the parasite plastid. Its potential impact on liver function is indicated by increases in various liver enzymes, and it shows transport activity with a Km value of 61.9 nM in mOat3-expressing oocytes. Despite its varied bioactivities, L-Carnitine has a DILI severity class of 0.0, suggesting no significant drug-induced liver injury. Additionally, L-Carnitine exhibits antiviral activity against SARS-CoV-2, albeit with weak potency, and does not show significant bioactivity against a range of tested receptors and enzymes, as indicated by AC50 values greater than 30000.0 nM. The totality of these findings points to its complex interaction profile with multiple biological pathways and potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	L-Carnitine (L(-)-Carnitine) is an amino acid derivative. L-Carnitine facilitates long-chain fatty acid entry into mitochondria, delivering substrate for oxidation and subsequent energy production. Fatty acids are utilized as an energy substrate in all tissues except the brain.
Synonyms	Levocarnitine, L(-)-Carnitine

Chemical Properties

Molecular Weight	161.20
Formula	C₇H₁₅NO₃
Cas No.	541-15-1
Smiles	C[N+](C)(C)C[C@@H](O)CC([O-])=O
Relative Density.	0.64 g/cm3

Storage & Solubility Information

Storage

keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 6.25 mg/mL (38.77 mM), Sonication is recommended.

H2O: 29 mg/mL (179.9 mM), Sonication is recommended.

Ethanol: 30 mg/mL (186.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O/Ethanol

	1mg	5mg	10mg	50mg
1 mM	6.2035 mL	31.0174 mL	62.0347 mL	310.1737 mL
5 mM	1.2407 mL	6.2035 mL	12.4069 mL	62.0347 mL
10 mM	0.6203 mL	3.1017 mL	6.2035 mL	31.0174 mL
20 mM	0.3102 mL	1.5509 mL	3.1017 mL	15.5087 mL

H2O/Ethanol

	1mg	5mg	10mg	50mg
50 mM	0.1241 mL	0.6203 mL	1.2407 mL	6.2035 mL
100 mM	0.0620 mL	0.3102 mL	0.6203 mL	3.1017 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc