Powder: -20°C for 3 years | In solvent: -80°C for 1 year
P-gp Inhibitor 13, a P-glycoprotein antagonist, can counteract paclitaxel resistance in A2780/T cells, proving valuable for advanced acute myeloid leukemia research [1].
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Description | P-gp Inhibitor 13, a P-glycoprotein antagonist, can counteract paclitaxel resistance in A2780/T cells, proving valuable for advanced acute myeloid leukemia research [1]. |
In vitro | P-gp inhibitor 13 (Compound 27f) demonstrated significant chemosensitization in A2780/T cells with an IC50 value of 0.010 μM [1]. It effectively increased the accumulation of paclitaxel and rhodamine 123 by inhibiting P-gp, thereby reversing multidrug resistance (MDR) [1]. Furthermore, P-gp inhibitor 13 exhibited minimal associated cardiotoxicity [1]. The compound also showed concentration-dependent MDR reversal activity in A2780/T cells at concentrations of 2.5 μM, 5 μM, 10 μM, and 20 μM [1]. |
Molecular Weight | 546.61 |
Formula | C32H34O8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
P-gp inhibitor 13 inhibitor inhibit