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Chebulic acid

Name: Chebulic acid
Brand: TargetMol
SKU: TN1042
Price: 122 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1042Cas No. 23725-05-5

Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, exhibits potent antioxidant activity by breaking protein cross-links induced by advanced glycation end-products (AGEs) and inhibiting AGE formation. It may also counteract AGE-induced endothelial cell dysfunction, suggesting it as a potential intervention for diabetic vascular complications.

Chebulic acid

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Purity: 99.98%

Catalog No. TN1042Cas No. 23725-05-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$122	In Stock	-
5 mg	$289	In Stock	-
10 mg	$455	In Stock	-
25 mg	$736	In Stock	-
50 mg	$987	Backorder	Backorder
1 mL x 10 mM (in DMSO)	$318	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.98%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, exhibits potent antioxidant activity by breaking protein cross-links induced by advanced glycation end-products (AGEs) and inhibiting AGE formation. It may also counteract AGE-induced endothelial cell dysfunction, suggesting it as a potential intervention for diabetic vascular complications.
In vitro	chebulic acid prevents the glycer-AGEs-induced ROS formation of LX-2 cells and collagen accumulation by ERK-phosphorylation-mediated Nrf2 nuclear translocation, which causes upregulation of antioxidant protein production[2].

Chemical Properties

Molecular Weight	356.24
Formula	C₁₄H₁₂O₁₁
Cas No.	23725-05-5
Smiles	OC(=O)C[C@@H]([C@@H]1[C@H](OC(=O)c2cc(O)c(O)c(O)c12)C(O)=O)C(O)=O
Relative Density.	1.882 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 260 mg/mL (729.85 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8071 mL	14.0355 mL	28.0710 mL	140.3548 mL
5 mM	0.5614 mL	2.8071 mL	5.6142 mL	28.0710 mL
10 mM	0.2807 mL	1.4035 mL	2.8071 mL	14.0355 mL
20 mM	0.1404 mL	0.7018 mL	1.4035 mL	7.0177 mL
50 mM	0.0561 mL	0.2807 mL	0.5614 mL	2.8071 mL
100 mM	0.0281 mL	0.1404 mL	0.2807 mL	1.4035 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc