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Bromhexine hydrochloride

Name: Bromhexine hydrochloride
Brand: TargetMol
SKU: T0828
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0828Cas No. 611-75-6

Alias Bromhexine HCl, Bisolvon, Auxit

Bromhexine hydrochloride (Bisolvon) is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.

Bromhexine hydrochloride

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Purity: 99.98%

Catalog No. T0828Alias Bromhexine HCl, Bisolvon, AuxitCas No. 611-75-6

Bromhexine hydrochloride (Bisolvon) is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$30	In Stock	In Stock
5 g	$33	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bromhexine hydrochloride AI Summary

Bromhexine hydrochloride exhibits a wide range of bioactivities across various assays related to cellular functions, enzyme inhibition, and antiviral properties. It shows potency in assays such as modulators of Lamin A splicing, inhibitors of ROR gamma transcriptional activity, activators and inhibitors of Cytochrome P450 3A4, compounds blocking the interaction between CBF-beta and RUNX1 for the treatment of acute myeloid leukemia, and inhibitors of the malarial parasite plastid. Additionally, it inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in both absence and presence of CPT. It also demonstrates the ability to inhibit the binding or entry into cells for Lassa Virus, Marburg Virus, and Ebola Virus. Specifically, it inhibits sodium fluorescein uptake in OATP1B3-transfected CHO cells by 95.98% and in OATP1B1-transfected CHO cells by 103.11% at a concentration of 10 µM. Despite its broad bioactivity, Bromhexine hydrochloride shows minimal activity in inhibiting cell viability of SARS-CoV-2 (strain BavPat1) infected Vero E6 cells, with a very low inhibition index of 0.00411. However, it exhibits modest antiviral activity against SARS-CoV-2, with an inhibition rate of -38.2% in Caco-2 cells at 10 µM after 48 hours. Furthermore, it inhibits the SARS-CoV-2 3CL-Pro protease by 13.35% at a concentration of 20 µM, as determined by a FRET assay using a peptide substrate. Lastly, Bromhexine hydrochloride inhibits SARS-CoV-2 induced cytotoxicity of VERO-6 cells at a 10 µM concentration after 48 hours exposure, with an inhibition rate of 0.29%, as determined by high content imaging..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Bromhexine hydrochloride (Bisolvon) is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.
Synonyms	Bromhexine HCl, Bisolvon, Auxit

Chemical Properties

Molecular Weight	412.59
Formula	C₁₄H₂₁Br₂ClN₂
Cas No.	611-75-6
Smiles	Cl.CN(Cc1cc(Br)cc(Br)c1N)C1CCCCC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5.63 mg/mL (13.65 mM), Sonication is recommended.

Ethanol: 5 mg/mL (12.12 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4237 mL	12.1186 mL	24.2371 mL	121.1857 mL
5 mM	0.4847 mL	2.4237 mL	4.8474 mL	24.2371 mL
10 mM	0.2424 mL	1.2119 mL	2.4237 mL	12.1186 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc