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Anti-CATSPER Polyclonal Antibody
😃Good
Catalog No. TMAB-03696
Anti-CATSPER Polyclonal Antibody is a Rabbit antibody targeting CATSPER. Anti-CATSPER Polyclonal Antibody can be used in WB.
Anti-CATSPER Polyclonal Antibody
Anti-CATSPER Polyclonal Antibody
😃Good
Catalog No. TMAB-03696
Anti-CATSPER Polyclonal Antibody is a Rabbit antibody targeting CATSPER. Anti-CATSPER Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-CATSPER Polyclonal Antibody is a Rabbit antibody targeting CATSPER. Anti-CATSPER Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Rat) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail. |
| Tissue Specificity | Testis-specific. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | CATSPER1 is a voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. It controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. It is activated by intracellular alkalinization. |
| Immunogen | KLH conjugated synthetic peptide: mouse CATSPER |
| Antigen Species | Mouse |
| Gene Name | CATSPER1 |
| Gene ID | |
| Protein Name | Cation channel sperm-associated protein 1 |
| Uniprot ID | |
| Function | Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. |
| Molecular Weight | Theoretical: 90 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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