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Lincomycin

Name: Lincomycin
Brand: TargetMol
SKU: T1235L
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1235LCas No. 154-21-2

Alias U-10149, U10149

Lincomycin (U-10149) is a lincosamide antibiotic from Streptomyces that is effective against most susceptible gram-positive and cell wall-less bacteria and is generally used in patients for whom penicillin is not available.

Lincomycin

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Purity: 99.77%

Catalog No. T1235LAlias U-10149, U10149Cas No. 154-21-2

Pack Size	Price	Availability
1 mg	$37	In Stock
5 mg	$85	In Stock
10 mg	$125	In Stock
25 mg	$198	In Stock
50 mg	$297	In Stock
100 mg	$497	In Stock
200 mg	$693	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock

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Purity:99.77%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Lincomycin (U-10149) is a lincosamide antibiotic from Streptomyces that is effective against most susceptible gram-positive and cell wall-less bacteria and is generally used in patients for whom penicillin is not available.
In vivo	Lincomycin (5 g/L in drinking water for 7 days) caused intestinal and liver injury, inflammation, and gut microbiota imbalance in 21-day-old ICR mice, indicating toxicity via the gut–liver axis[1].
Synonyms	U-10149, U10149

Chemical Properties

Molecular Weight	406.54
Formula	C₁₈H₃₄N₂O₆S
Cas No.	154-21-2
Smiles	[C@@H](NC(=O)[C@@H]1C[C@@H](CCC)CN1C)([C@@H](C)O)[C@]2(O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[H]
Relative Density.	1.29 g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (196.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4598 mL	12.2989 mL	24.5978 mL	122.9891 mL
5 mM	0.4920 mL	2.4598 mL	4.9196 mL	24.5978 mL
10 mM	0.2460 mL	1.2299 mL	2.4598 mL	12.2989 mL
20 mM	0.1230 mL	0.6149 mL	1.2299 mL	6.1495 mL
50 mM	0.0492 mL	0.2460 mL	0.4920 mL	2.4598 mL
100 mM	0.0246 mL	0.1230 mL	0.2460 mL	1.2299 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc