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Herniarin

Name: Herniarin
Brand: TargetMol
SKU: T7049
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7049Cas No. 531-59-9

Alias Methyl umbelliferyl ether, Herniarine, Ayapanin, 7-Methoxycoumarin

Herniarin (Ayapanin) is a natural coumarin with antitumor effect.

Herniarin

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Purity: 99.88%

Catalog No. T7049Alias Methyl umbelliferyl ether, Herniarine, Ayapanin, 7-MethoxycoumarinCas No. 531-59-9

Herniarin (Ayapanin) is a natural coumarin with antitumor effect.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$31	-	In Stock
1 g	$38	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	Herniarin (Ayapanin) is a natural coumarin with antitumor effect.
In vitro	Herniarin is cytotoxic to the breast carcinoma cell line MCF-7 (IC50: 207.6 μM) and induces apoptosis in MCF-7 cells at 100 μM [1]. While Herniarin alone shows no significant cytotoxicity on transitional cell carcinoma (TCC) cells, it significantly enhances the antitumor effect of cisplatin (5 μg/mL) at 80 μg/mL and increases chromatin condensation [2].
Synonyms	Methyl umbelliferyl ether, Herniarine, Ayapanin, 7-Methoxycoumarin

Chemical Properties

Molecular Weight	176.17
Formula	C₁₀H₈O₃
Cas No.	531-59-9
Smiles	O(C)C=1C=C2C(=CC1)C=CC(=O)O2
Relative Density.	1.248 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (283.82 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6763 mL	28.3817 mL	56.7634 mL	283.8168 mL
5 mM	1.1353 mL	5.6763 mL	11.3527 mL	56.7634 mL
10 mM	0.5676 mL	2.8382 mL	5.6763 mL	28.3817 mL
20 mM	0.2838 mL	1.4191 mL	2.8382 mL	14.1908 mL
50 mM	0.1135 mL	0.5676 mL	1.1353 mL	5.6763 mL
100 mM	0.0568 mL	0.2838 mL	0.5676 mL	2.8382 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc