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DHFR-IN-3

Name: DHFR-IN-3
Brand: TargetMol
SKU: T3693
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3693Cas No. 137553-43-6

Alias 7-bromoquinazoline-2,4-diamine

DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is a dihydrofolate reductase (DHFR) inhibitor.

DHFR-IN-3

🥰Excellent

Purity: 99.65%

Catalog No. T3693Alias 7-bromoquinazoline-2,4-diamineCas No. 137553-43-6

DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is a dihydrofolate reductase (DHFR) inhibitor.

Pack Size	Price	Availability	Quantity
100 mg	$29	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:99.65%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is a dihydrofolate reductase (DHFR) inhibitor.
Synonyms	7-bromoquinazoline-2,4-diamine

Chemical Properties

Molecular Weight	239.07
Formula	C₈H₇BrN₄
Cas No.	137553-43-6
Smiles	NC1=NC2=CC(Br)=CC=C2C(N)=N1
Relative Density.	1.828g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (230.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1829 mL	20.9144 mL	41.8288 mL	209.1438 mL
5 mM	0.8366 mL	4.1829 mL	8.3658 mL	41.8288 mL
10 mM	0.4183 mL	2.0914 mL	4.1829 mL	20.9144 mL
20 mM	0.2091 mL	1.0457 mL	2.0914 mL	10.4572 mL
50 mM	0.0837 mL	0.4183 mL	0.8366 mL	4.1829 mL
100 mM	0.0418 mL	0.2091 mL	0.4183 mL	2.0914 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc