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Sibiromycin
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Catalog No. T38673Cas No. 12684-33-2
Sibiromycin, a glycosylated pyrrolobenzodiazepines (PBDs) compound, is a naturally occurring and potent antitumor antibiotic. It exerts its activity by covalently binding to DNA in the minor groove at the NH2 of guanine.
Sibiromycin
Copy Product Info😃Good
Catalog No. T38673Cas No. 12684-33-2
Sibiromycin, a glycosylated pyrrolobenzodiazepines (PBDs) compound, is a naturally occurring and potent antitumor antibiotic. It exerts its activity by covalently binding to DNA in the minor groove at the NH2 of guanine.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $1,290 | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
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| Description | Sibiromycin, a glycosylated pyrrolobenzodiazepines (PBDs) compound, is a naturally occurring and potent antitumor antibiotic. It exerts its activity by covalently binding to DNA in the minor groove at the NH2 of guanine. |
| In vitro | Pyrrolobenzodiazepines (PBDs) are highly specific DNA alkylating agents known for their exceptional antineoplastic properties, effectively targeting and binding to DNA sequences with a preference order of 5′-Pu-G-Pu>5′-Py-G-Pu>5′-Pu-G-Py>5′-Py-G-Py. Among them, anthramycin, sibiromycin, and tomaymycin demonstrate this sequence-specific action. Notably, sibiromycin exhibits potent cytotoxic capabilities against various cell lines, including L1210 (leukemia), ADJ/PC6 (plasmacytoma), and CH1 (ovarian), with half-maximal inhibitory concentrations (IC50s) ranging from 0.000017 to 0.0029 μM, highlighting its potential as a therapeutic agent. |
| Molecular Weight | 475.542 |
| Formula | C24H33N3O7 |
| Cas No. | 12684-33-2 |
| Smiles | [H][C@@]12CC(\C=C\C)=CN1C(=O)c1cc(O[C@@H]3O[C@@H](C)[C@H](NC)[C@@](C)(O)[C@H]3O)c(C)c(O)c1N[C@@H]2O |c:6| |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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