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Sibiromycin

Catalog No. T38673 CAS 12684-33-2

Sibiromycin, a glycosylated pyrrolobenzodiazepines (PBDs) compound, is a naturally occurring and potent antitumor antibiotic. It exerts its activity by covalently binding to DNA in the minor groove at the NH2 of guanine.

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Sibiromycin, CAS 12684-33-2

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

Pyrrolobenzodiazepines (PBDs) are highly specific DNA alkylating agents known for their exceptional antineoplastic properties, effectively targeting and binding to DNA sequences with a preference order of 5′-Pu-G-Pu>5′-Py-G-Pu>5′-Pu-G-Py>5′-Py-G-Py. Among them, anthramycin, sibiromycin, and tomaymycin demonstrate this sequence-specific action. Notably, sibiromycin exhibits potent cytotoxic capabilities against various cell lines, including L1210 (leukemia), ADJ/PC6 (plasmacytoma), and CH1 (ovarian), with half-maximal inhibitory concentrations (IC50s) ranging from 0.000017 to 0.0029 μM, highlighting its potential as a therapeutic agent.

Molecular Weight	475.542
Formula	C24H33N3O7
CAS No.	12684-33-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Gerratana B. Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines. Med Res Rev. 2012;32(2):254-293. 2. Li W, et al. Biosynthesis of sibiromycin, a potent antitumor antibiotic. Appl Environ Microbiol. 2009;75(9):2869-2878.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Sibiromycin 12684-33-2 inhibitor inhibit

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