Shopping Cart

Your shopping cart is currently empty

Cytosporone B

Name: Cytosporone B
Brand: TargetMol
SKU: T3976
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T3976Cas No. 321661-62-5

Alias Dothiorelone G, Csn-B

Cytosporone B (Dothiorelone G) is a naturally occurring agonist of the nuclear orphan receptor Nur77/NR4A1 (EC50=0.278 nM).

Cytosporone B

Copy Product Info

😃Good

Purity: 99.72%

Catalog No. T3976Alias Dothiorelone G, Csn-BCas No. 321661-62-5

Cytosporone B (Dothiorelone G) is a naturally occurring agonist of the nuclear orphan receptor Nur77/NR4A1 (EC50=0.278 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$39	In Stock	In Stock
5 mg	$59	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$197	In Stock	In Stock
50 mg	$317	In Stock	In Stock
100 mg	$469	-	In Stock
500 mg	$1,050	-	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.72%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Cytosporone B (Dothiorelone G) is a naturally occurring agonist of the nuclear orphan receptor Nur77/NR4A1 (EC50=0.278 nM).
Targets&IC50	Nur77:0.278 nM
In vitro	Cytosporone B targets the ligand-binding domain of Nur77, Cytosporone B induced fluorokinase activity in cells cotransfected with GAL4-Nur77 or GAL4-LBD, the EC50 of Cytosporone B for Nur77 is 0.278 nM. Cytosporone B had an inhibitory effect on the proliferation of human cancer BGC- 823 cells and human cancer SW620 cells by greater than 70%, but had modest inhibitory effect on human cancer H1299 cells and human hepatocellular carcinoma HepG2 cells by greater than or equal to 40%. [1]
In vivo	In wild-type mice, Cytosporone B treatment significantly increased glucose levels from 3.2 mM to 11.4 mM within the first 30 minutes, after which blood glucose gradually decreased, reaching initial levels after 300 minutes. [1]
Synonyms	Dothiorelone G, Csn-B

Chemical Properties

Molecular Weight	322.4
Formula	C₁₈H₂₆O₅
Cas No.	321661-62-5
Smiles	CCCCCCCC(=O)c1c(O)cc(O)cc1CC(=O)OCC
Relative Density.	1.126 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (387.72 mM), Sonication is recommended.

In Vivo Formulation

2% DMSO＋98% (20% SBE-β-CD in Saline): 2 mg/mL (6.2 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1017 mL	15.5087 mL	31.0174 mL	155.0868 mL
5 mM	0.6203 mL	3.1017 mL	6.2035 mL	31.0174 mL
10 mM	0.3102 mL	1.5509 mL	3.1017 mL	15.5087 mL
20 mM	0.1551 mL	0.7754 mL	1.5509 mL	7.7543 mL
50 mM	0.0620 mL	0.3102 mL	0.6203 mL	3.1017 mL
100 mM	0.0310 mL	0.1551 mL	0.3102 mL	1.5509 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc