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N-Acetyl-L-leucine
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Catalog No. T4798Cas No. 1188-21-2
Alias Levacetylleucine
N-Acetylleucine belongs to the class of organic compounds known as leucine and derivatives. Leucine and derivatives are compounds containing leucine or a derivative thereof resulting from reaction of leucine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. N-Acetylleucine is soluble (in water) and a weakly acidic compound (based on its pKa). N-Acetylleucine has been detected in multiple biofluids, such as feces and saliva.
N-Acetyl-L-leucine
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Purity: 99.89%
Catalog No. T4798Alias LevacetylleucineCas No. 1188-21-2
N-Acetylleucine belongs to the class of organic compounds known as leucine and derivatives. Leucine and derivatives are compounds containing leucine or a derivative thereof resulting from reaction of leucine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. N-Acetylleucine is soluble (in water) and a weakly acidic compound (based on its pKa). N-Acetylleucine has been detected in multiple biofluids, such as feces and saliva.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $41 | In Stock | In Stock | |
| 1 g | $48 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $45 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.89%
Appearance:Solid
Color:White
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Product Introduction
N-Acetyl-L-leucine AI Summary
N-Acetyl-L-leucine exhibits notable hydrophilic properties with a partition coefficient (logP) of -2.61 and a bitter threshold value indicated by Log 1/T = 1.65. It shows bioactivity in inhibiting Aldehyde Dehydrogenase 1 (ALDH1A1) with a potency of 6309.6 nM and exhibits antiviral activity by blocking Ebola Virus entry with an AC50 value of 7943.3 nM. The compound inhibits sodium fluorescein uptake in OATP1B3-transfected CHO cells by 99.12% and in OATP1B1-transfected CHO cells by 65.92% at a concentration of 10 uM.
Regarding its activity against SARS-CoV-2, N-Acetyl-L-leucine shows limited efficacy in inhibiting cell viability in Vero E6 cells (inhibition index of 0.0661) but demonstrates some antiviral effects by reducing cytotoxicity in Caco-2 cells (11.23% inhibition at 10 uM) and HRCE cells (hit score of 0.1332). Additionally, it exhibits 32.89% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. In VERO-6 cells, the compound shows moderate antiviral activity with an IC50 value greater than 20000.0 nM and an inhibition rate of -0.04% at 10 uM after 48 hours of exposure.
Furthermore, N-Acetyl-L-leucine inhibits human HDAC6 enzyme activity using both commercial and custom peptide substrates, suggesting potential therapeutic applications as an HDAC6 inhibitor..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | N-Acetylleucine belongs to the class of organic compounds known as leucine and derivatives. Leucine and derivatives are compounds containing leucine or a derivative thereof resulting from reaction of leucine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. N-Acetylleucine is soluble (in water) and a weakly acidic compound (based on its pKa). N-Acetylleucine has been detected in multiple biofluids, such as feces and saliva. |
| Synonyms | Levacetylleucine |
| Molecular Weight | 173.21 |
| Formula | C8H15NO3 |
| Cas No. | 1188-21-2 |
| Smiles | CC(C)C[C@H](NC(C)=O)C(O)=O |
| Relative Density. | 1.1599 g/cm3 (Estimated) |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (1443.33 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.55 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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