Shopping Cart
Remove All
Your shopping cart is currently empty
Anti-CSEN Polyclonal Antibody
😃Good
Catalog No. TMAB-04720
Anti-CSEN Polyclonal Antibody is a Rabbit antibody targeting CSEN. Anti-CSEN Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Anti-CSEN Polyclonal Antibody
Anti-CSEN Polyclonal Antibody
😃Good
Catalog No. TMAB-04720
Anti-CSEN Polyclonal Antibody is a Rabbit antibody targeting CSEN. Anti-CSEN Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Resource Download
Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-CSEN Polyclonal Antibody is a Rabbit antibody targeting CSEN. Anti-CSEN Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Dog,Pig,Cow,Rabbit) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:50-200 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Cell membrane. Endoplasmic reticulum. Golgi apparatus. Nucleus. Also membrane-bound, associated with the plasma membrane (By similarity). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. |
| Tissue Specificity | Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | CSEN is a Ca2+-regulated transcriptional repressor that specifically binds to the downstream regulatory elements (DRE). DRE is a regulatory sequence that silences basal transcription and is localized to the promoter region of the gene encoding human prodynorphin, an opioid peptide involved in memory acquisition and pain. DREAM forms functional homotetramers that are required for the interaction with the DRE. This association is highly influenced by calcium, as an increase in Ca2+ directly inhibits DREAM binding and thereby blocks the repressor activity of DREAM. DREAM transcripts are detected in brain, thymus and thyroid gland, and it is expressed as a nuclear protein. DREAM has been shown to inhibit transcription of other proteins containing DRE-like motifs, including the gene encoding for the AP-1 transcription factor c-Fos, suggesting that DREAM may influence a wide variety of cellular genes. |
| Immunogen | KLH conjugated synthetic peptide: human CSEN |
| Antigen Species | Human |
| Gene Name | KCNIP3 |
| Gene ID | |
| Protein Name | Calsenilin |
| Uniprot ID | |
| Function | Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception.
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and probably KCND3 trafficking to the cell surface. May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation. |
| Molecular Weight | Theoretical: 28 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Calculator
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Anti-CSEN Polyclonal Antibody | purchase Anti-CSEN Polyclonal Antibody | Anti-CSEN Polyclonal Antibody cost | order Anti-CSEN Polyclonal Antibody | Anti-CSEN Polyclonal Antibody molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.