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Anti-PRDM16 Antibody (2M360)

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Catalog No. TMAB-11718

Anti-PRDM16 Antibody (2M360) is a Mouse antibody targeting PRDM16. Anti-PRDM16 Antibody (2M360) can be used in WB.

Anti-PRDM16 Antibody (2M360)

Anti-PRDM16 Antibody (2M360)

😃Good
Catalog No. TMAB-11718
Anti-PRDM16 Antibody (2M360) is a Mouse antibody targeting PRDM16. Anti-PRDM16 Antibody (2M360) can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2227-10 days7-10 days
100 μL$3737-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-PRDM16 Antibody (2M360) is a Mouse antibody targeting PRDM16. Anti-PRDM16 Antibody (2M360) can be used in WB.
Ig Type
IgG1, k
Clone
2M360
Reactivity
Human
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationNucleus.
Tissue SpecificityExpressed in uterus and kidney.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Antigen Details
Immunogen
Recombinant Protein: human PRDM16 between 779-996 amino acids
Antigen Species
Human
Gene Name
PRDM16
Gene ID
63976
Protein Name
Histone-lysine N-methyltransferase PRDM16
Uniprot ID
Q9HAZ2
Function
Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation.
Chemical Properties
Molecular WeightTheoretical: 150 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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