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Phenylalanylalanine

Name: Phenylalanylalanine
Brand: TargetMol
SKU: T40490
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40490Cas No. 3918-87-4

Alias H-Phe-Ala-OH

Phenylalanylalanine (H-Phe-Ala-OH) is a dipeptide composed of phenylalanine and alanine, produced during incomplete protein digestion or catabolism [1].

Phenylalanylalanine

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Purity: 99.56%

Catalog No. T40490Alias H-Phe-Ala-OHCas No. 3918-87-4

Phenylalanylalanine (H-Phe-Ala-OH) is a dipeptide composed of phenylalanine and alanine, produced during incomplete protein digestion or catabolism [1].

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.56%

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COA HNMR LCMS

Product Introduction

Phenylalanylalanine AI Summary

Phenylalanylalanine exhibits diverse bioactivities, showing significant inhibitory effects on various peptide transporters and enzymes. It acts as an inhibitor of the human intestinal peptide transporter PepT1 with a Ki value of 180.0 nM and the renal peptide transporter PepT2 with a Ki value of approximately 13,100.0 nM. Additionally, it inhibits enkephalinase from mouse striatum at an IC50 value of 1,000.0 nM but shows minimal activity against mouse striatum Angiotensin I converting enzyme with an IC50 greater than 1,000,000.0 nM. In SKPT cells, the IC50 values are 15,500.0 nM for PepT2. In other assays, it serves as a substrate for the TP_TRANSPORTER with a Km value of 56,600.0 nM and demonstrates uptake activity at pH 6.0 in Xenopus laevis oocytes. Finally, it inhibits UBR protein in rabbit reticulocyte lysates, prolonging the half-life of the Tyr-nsP4 substrate to 1.03 hours at 2 mM concentration and displaying an IC50 of 342,000.0 nM in a separate degradation assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Phenylalanylalanine (H-Phe-Ala-OH) is a dipeptide composed of phenylalanine and alanine, produced during incomplete protein digestion or catabolism [1].
Synonyms	H-Phe-Ala-OH

Chemical Properties

Molecular Weight	236.27
Formula	C₁₂H₁₆N₂O₃
Cas No.	3918-87-4
Smiles	CC(NC(=O)C(N)Cc1ccccc1)C(O)=O
Sequence	Phe-Ala
Sequence Short	FA

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4 mg/mL (16.93 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2324 mL	21.1622 mL	42.3245 mL	211.6223 mL
5 mM	0.8465 mL	4.2324 mL	8.4649 mL	42.3245 mL
10 mM	0.4232 mL	2.1162 mL	4.2324 mL	21.1622 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc