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Angelicin

Name: Angelicin
Brand: TargetMol
SKU: T2875
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2875Cas No. 523-50-2

Alias Isopsoralen

Angelicin (Isopsoralen), is a furanocoumarin with anti-Y, antiviral, anti-inflammatory activity.

Angelicin

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Purity: 99.89%

Catalog No. T2875Alias IsopsoralenCas No. 523-50-2

Angelicin (Isopsoralen), is a furanocoumarin with anti-Y, antiviral, anti-inflammatory activity.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$38	In Stock	In Stock
50 mg	$53	In Stock	In Stock
100 mg	$74	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Color:White

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COA HPLC HNMR

Product Introduction

Angelicin AI Summary

Angelicin demonstrates significant bioactivity with a range of inhibitory effects across various biological targets and environments. It shows cytotoxicity against multiple human cell lines, including HL-60, LoVo, NCTC-2544, Jurkat, MCF7, A549, and K562, with phototoxicity being particularly pronounced when cells are exposed to UVA irradiation, resulting in different IC50 and GI50 values across cell types, indicating varying potency. The compound is notably effective in inhibiting cell growth and inducing cell death post-UVA irradiation, as evidenced by its low IC50 values in HT1080 human fibrosarcoma cells. Additionally, Angelicin inhibits DNA and RNA synthesis in Ehrlich Ascites tumor cells with remarkably low D50 values at specific irradiations (365nm). It exhibits moderate water solubility (20.0 µg/mL), a binding constant (K) of 560.0 with calf thymus DNA, and photoreactive rate constant of 0.011 min⁻¹. The compound also inhibits DNA synthesis in mouse epidermal cells and shows moderate antiproliferative effects compared to 8-methoxypsoralen. Furthermore, Angelicin inhibits the NF-KB p50 subunit/DNA interaction with an IC50 of 2.5 nM and exhibits inhibitory effects on several enzymes, including BACE1 (though weakly at high concentrations), recombinant human CYP1A1 (80% inhibition at 10 µM), ALDH3A1, ALDH1A1, ALDH2, with substantial inhibition, and monoamine oxidase (MAO) A and B, with a higher selectivity towards MAO-A (IC50 values ranging from 880.0 nM to 9000.0 nM). It competitively inhibits MAO-A with a Ki value of 460.0 nM and shows inhibitory activity against electric eel AChE (IC50 value of 25400.0 nM). Overall, Angelicin exhibits a broad spectrum of biological activities, supporting its potential as a therapeutic agent in cancer treatment as well as a molecular tool for studying DNA interactions, enzyme inhibition, and cell cycle regulation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Angelicin (Isopsoralen), is a furanocoumarin with anti-Y, antiviral, anti-inflammatory activity.
Synonyms	Isopsoralen

Chemical Properties

Molecular Weight	186.16
Formula	C₁₁H₆O₃
Cas No.	523-50-2
Smiles	O=c1ccc2ccc3occc3c2o1
Relative Density.	1.389 ± 0.06 g/cm3

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 52.1 mg/mL (279.87 mM)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.3717 mL	26.8586 mL	53.7172 mL	268.5862 mL
5 mM	1.0743 mL	5.3717 mL	10.7434 mL	53.7172 mL
10 mM	0.5372 mL	2.6859 mL	5.3717 mL	26.8586 mL
20 mM	0.2686 mL	1.3429 mL	2.6859 mL	13.4293 mL
50 mM	0.1074 mL	0.5372 mL	1.0743 mL	5.3717 mL
100 mM	0.0537 mL	0.2686 mL	0.5372 mL	2.6859 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc