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CWP232228

🥰Excellent
Catalog No. T10904Cas No. 1144044-02-9

CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting the growth of breast cancer and liver cancer stem cells (CSC) without toxicity.

CWP232228

CWP232228

🥰Excellent
Purity: 98.87%
Catalog No. T10904Cas No. 1144044-02-9
CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting the growth of breast cancer and liver cancer stem cells (CSC) without toxicity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$140In StockIn Stock
5 mg$298In StockIn Stock
10 mg$433In StockIn Stock
25 mg$678In StockIn Stock
50 mg$912-In Stock
100 mg$1,180-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.87%
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Product Introduction

Bioactivity
Description
CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting the growth of breast cancer and liver cancer stem cells (CSC) without toxicity.
In vitro
CWP232228 (0.01-100 μM; 48 hours) inhibited cell proliferation, with IC50 values of 2 μM in mouse (4T1) and 0.8 μM in human (MDA-MB-435) breast cancer cell lines. In Hep3B, Huh7, and HepG2 cells, CWP232228 (0.01-10 μM; 48 hours) demonstrated IC50 values of 2.566, 2.630, and 2.596 μM, respectively.
In vivo
CWP232228 (100 mg/kg, administered i.p.; daily; mice with 4T1 cell tumors for 21 days; mice with MDA-MB-435 cell tumors for 60 days) significantly reduced tumor volume.
Chemical Properties
Molecular Weight717.63
FormulaC33H34N7Na2O7P
Cas No.1144044-02-9
SmilesO=C(NCC1=CC=CC=C1)N(N(CC2=O)CC=C)[C@]([H])(N2[C@H](C3=O)CC4=CC=C(C=C4)OP([O-])([O-])=O)CN3CC5=CC=CC6=CN(N=C56)C.[Na+].[Na+]
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 60.00 mg/mL (83.61 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM1.3935 mL6.9674 mL13.9348 mL69.6738 mL
5 mM0.2787 mL1.3935 mL2.7870 mL13.9348 mL
10 mM0.1393 mL0.6967 mL1.3935 mL6.9674 mL
20 mM0.0697 mL0.3484 mL0.6967 mL3.4837 mL
50 mM0.0279 mL0.1393 mL0.2787 mL1.3935 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

β-cateninβcateninWnt/β-cateninWnt/betacateninWnt/b-cateninWntstemsignalingliverInhibitorinhibitCWP-232228CWP232228CWP 232228cellsCancerBreastbeta-cateninbetacateninBeta cateninbcatenin
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