Macrocyclic Compound Library

Catalog No. L9300

Library Compound List Excel SDF

Macrocyclic compounds are highly significant in drug and research development. When developing new drugs, macrocyclic compound are commonly researched in the medical field. Macrocyclic compounds are becoming more successfully recognised as an approach for low drug availability targets, such as antimicrobial, antiviral, and protein-protein interactions (PPIs). Topologically, macrocyclic compounds have a unique ability to span large surface areas whilst remaining conformationally restricted when compared to acyclic molecules of equivalent molecular weight. Macrocyclic compounds also reduce the overall polarity and enhance membrane permeability. Therefore, together these attributes make macrocycles a powerful approach for any lead discovery programme against challenging targets.

Research into macrocyclic compounds is increasing and are widely used in antibacterial, antiviral, and antitumor drugs for clinical applications. On antibacterial aspects, macrolides, cyclic peptides, aza-macrocyclic compounds, etc., for example, have the characteristics of broad antibacterial spectrum antibiotics. They also exhibit strong antibacterial activity, remarkable curative effect and circumvent drug resistance.

Clinical application of anti-herpes virus drugs, like ganciclovir and cidofovir have severe side effects with poor antiviral activity. Presently, attention is focused on research of naphthyridines. Some compounds already synthesised via computer technology are already exhibiting strong anti-herpes virus activity.

On anti-tumour aspects, epothilone has a similar mechanism of action as paclitaxel. Epothilone is highly toxic to cells that have developed resistance to paclitaxel, therefore overcomes the weakness displayed by paclitaxel.

With the continuous development of chemical synthesis technology, the discovery of macrocyclic lead compounds from natural products, improvement of the availability of genomic sequences and bioinformatics have marked the arrival of times of the exploration of new macrocyclic drugs. As research progresses macrocyclic drugs are sure to have a bright application prospect.

TargetMol’s Macrocyclic Compound Library collects 216 macrocyclic compounds of known activity for the study of macrocyclic drugs.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

Request for Quote

If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

Request Library

Product Description

216 macrocyclic compounds of known activity for high-throughput, high-content screening;
A powerful tool for studying antibacterial, antiviral, and protein-protein interactions, etc.;
Most of them are already approved, with information regarding biosafety and biological activity;
NMR and HPLC validated to ensure high purity and quality;
All compounds are available from stock supplies.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

10. Blood. 2021, 137(11): 1478-1490. 11. Nucleic Acids Research. 2021. 12. Nature Communications. 2023, 14(1): 7574. 13. Advanced Science. 2020, 7(16): 2000925. 14. Angewandte Chemie. 2021. 15. Acta Pharmaceutica Sinica B. 2022. 16. Protein & Cell. 2021, 12(11): 877-888. 17. Bone Research. 2023, 11(1): 54. 18. Pharmacology & Therapeutics. (2021): 107930. 19. Nature Communications. 2021, 12(1): 1-12. 20. Journal of Cell Biology. 2022, 221(5): e202112024.

See More... Hide

Library Composition

Antibiotic (69)

Antibacterial (52)

Autophagy (28)

Apoptosis (26)

Microtubule Associated (14)

Antifungal (13)

Parasite (10)

ribosome (9)

Endogenous Metabolite (9)

HIV Protease (8)

NF-κB (7)

DNA/RNA Synthesis (7)

Integrin (7)

mTOR (6)

Phosphatase (5)

TNF (5)

SARS-CoV (5)

HCV Protease (5)

HSP (5)

Mitophagy (4)

JAK (4)

P450 (4)

HSV (4)

P-gp (4)

Vasopressin Receptor (4)

Reactive Oxygen Species (4)

Estrogen/progestogen Receptor (3)

Influenza Virus (3)

Tyrosine Kinases (3)

Melanocortin Receptor (3)

Antioxidant (3)

FLT (3)

Potassium Channel (3)

Oxytocin Receptor (3)

Sodium Channel (3)

ROS (3)

CXCR (3)

TLR (2)

Telomerase (2)

Somatostatin (2)

Trk receptor (2)

P2X Receptor (2)

ROS Kinase (2)

Interleukin (2)

Virus Protease (2)

IL Receptor (2)

MMP (2)

AChR (2)

HDAC (2)

Cell wall (2)

Guanylate cyclase (2)

ALK (2)

Complement System (2)

COX (2)

GluCls (2)

FAK (2)

ATPase (2)

Calcium Channel (2)

Histamine Receptor (1)

Src (1)

CDK (1)

Cannabinoid Receptor (1)

CaMK (1)

Bcr-Abl (1)

TGF-beta/Smad (1)

STAT (1)

TAM Receptor (1)

BCL (1)

Chloride channel (1)

Antifection (1)

Topoisomerase (1)

Androgen Receptor (1)

AMPK (1)

VDA (1)

Akt (1)

Reverse Transcriptase (1)

Platelet aggregation (1)

PTEN (1)

ERK (1)

HBV (1)

GST (1)

IκB/IKK (1)

Glucosidase (1)

JNK (1)

Glucocorticoid Receptor (1)

GABA Receptor (1)

MRP (1)

Estrogen Receptor/ERR (1)

NOD-like Receptor (NLR) (1)

Progesterone Receptor (1)

Epigenetic Reader Domain (1)

Endothelin Receptor (1)

EGFR (1)

Dehydrogenase (1)

CRISPR/Cas9 (1)

PI3K (1)

PKC (1)

Adrenergic Receptor (1)

c-Met/HGFR (1)

YAP (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty