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Anti-Caspase-6 Antibody (5J689) (Synonyms: OTTHUMP00000162743, OTTHUMP00000162742, MCH2, Caspase-6 subunit p1...)

Catalog No. TMAC-00586 Copy Product Info
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Anti-Caspase-6 Antibody (5J689) is a Rabbit antibody targeting Caspase-6. Anti-Caspase-6 Antibody (5J689) can be used in ICC/IF,IHC,IP,WB.

Anti-Caspase-6 Antibody (5J689)

Copy Product Info
🥰Excellent
Catalog No. TMAC-00586
Synonyms OTTHUMP00000162743, OTTHUMP00000162742, MCH2, Caspase-6 subunit p11, Caspase6, Caspase 6, apoptosis related cysteine peptidase, Caspase 6 apoptosis related cysteine protease, CASP6_HUMAN, CASP-6, CASP6, Apoptotic protease Mch-2, Apoptotic protease MCH2

Anti-Caspase-6 Antibody (5J689) is a Rabbit antibody targeting Caspase-6. Anti-Caspase-6 Antibody (5J689) can be used in ICC/IF,IHC,IP,WB.

Anti-Caspase-6 Antibody
(5J689)
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2967-10 days7-10 days
100 μL$4987-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-Caspase-6 Antibody (5J689) is a Rabbit antibody targeting Caspase-6. Anti-Caspase-6 Antibody (5J689) can be used in ICC/IF,IHC,IP,WB.
SynonymsOTTHUMP00000162743, OTTHUMP00000162742, MCH2, Caspase-6 subunit p11, Caspase6, Caspase 6, apoptosis related cysteine peptidase, Caspase 6 apoptosis related cysteine protease, CASP6_HUMAN, CASP-6, CASP6, Apoptotic protease Mch-2, Apoptotic protease MCH2
Ig Type
IgG
Clone
5J689
Reactivity
Human,Mouse,Rat
Verified Activity
1. Western blot analysis of Caspase-6 on different lysates using anti-Caspase-6 antibody at 1/1,000 dilution. Positive control: Lane 1: Mouse colon, Lane 2: MCF-7.
2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Caspase-6 antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Caspase-6 antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-Caspase-6 antibody. Counter stained with hematoxylin.
5. ICC staining Caspase-6 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
verifiedActivityverifiedActivityverifiedActivityverifiedActivityverifiedActivity
Application
Recommended Dose
WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundA unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9 and caspase-10. Ced-3/ caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose)polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins, which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 11/33 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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