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Neladalkib TFA
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Catalog No. T212650
Alias NVL-655 TFA
NeladalkibTFA is the TFA salt form of Neladalkib. Neladalkib (NVL-655) is an orally available ALK inhibitor, exhibiting an IC50 of 2.8 nM against ALK. It induces apoptosis and demonstrates antitumor activity.
Neladalkib TFA
Neladalkib TFA
Copy Product Info😃Good
Catalog No. T212650Alias NVL-655 TFA
NeladalkibTFA is the TFA salt form of Neladalkib. Neladalkib (NVL-655) is an orally available ALK inhibitor, exhibiting an IC50 of 2.8 nM against ALK. It induces apoptosis and demonstrates antitumor activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NeladalkibTFA is the TFA salt form of Neladalkib. Neladalkib (NVL-655) is an orally available ALK inhibitor, exhibiting an IC50 of 2.8 nM against ALK. It induces apoptosis and demonstrates antitumor activity. |
| In vitro | Neladalkib TFA exhibits an IC50 of 2.7 nM in Ba/F3 CLIP1-LTK cells. It demonstrates strong inhibitory effects on various ALK mutations, including ALK T1151insT, ALK T1151M, ALK L1152R, ALK C1156Y, ALK I1171N, ALK I1171S, ALK I1171T, ALK F1174L, ALK F1174S, ALK V1180L, ALK L1198F, ALK G1202R, ALK D1203N, ALK S1206R, and ALK R1275Q, with IC50 values ranging from 0.9 to 6.8 nmol/L. In contrast, it shows weaker inhibition against ALK G1196M, ALK G1269A, and ALK G1269S, with IC50 values between 11 and 79 nmol/L. Additionally, Neladalkib (1-100 nM, 24 h) TFA increases caspase 3/7 activation and decreases S phase cells, promoting apoptosis in NCI-H3122 cells. |
| In vivo | Neladalkib (0.06-1.5 mg/kg, orally, twice daily, for 0-28 days) TFA exhibits antitumor activity in mice. |
| Synonyms | NVL-655 TFA |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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