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Mapatumumab
🥰Excellent
Catalog No. T77371Cas No. 658052-09-6
Alias HGS-ETR1, HGSETR1, HGS-1012, HGS1012, Anti-Human TNFRSF10A Recombinant Antibody
Mapatumumab (HGS-ETR1) is a fully human agonistic monoclonal antibody targeting TNF-related apoptosis-inducing ligand receptor 1, with anticancer activity, capable of inducing apoptosis in cancer cells.
Mapatumumab
Mapatumumab
🥰Excellent
Purity: 97.85% (SEC-HPLC)
Catalog No. T77371Alias HGS-ETR1, HGSETR1, HGS-1012, HGS1012, Anti-Human TNFRSF10A Recombinant AntibodyCas No. 658052-09-6
Mapatumumab (HGS-ETR1) is a fully human agonistic monoclonal antibody targeting TNF-related apoptosis-inducing ligand receptor 1, with anticancer activity, capable of inducing apoptosis in cancer cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $249 | In Stock | |
| 5 mg | $747 | In Stock | |
| 10 mg | $1,190 | In Stock | |
| 25 mg | $1,990 | In Stock |
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Concentration:11.71 mg/mL
Purity:97.85% (SEC-HPLC)
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Product Introduction
Bioactivity
Chemical Properties
| Description | Mapatumumab (HGS-ETR1) is a fully human agonistic monoclonal antibody targeting TNF-related apoptosis-inducing ligand receptor 1, with anticancer activity, capable of inducing apoptosis in cancer cells. |
| Targets&IC50 | TNFRSF10A/TRAILR1 (human):17.21 ng/mL (EC50) |
| In vitro | Mapatumumab (0.01-100 μg/mL) showed very limited activity against 23 cell lines of PPTP cultured in vitro, with no cell lines achieving 50% growth inhibition. [1] Mapatumumab (1-100 ng/ml) and EPI (0.1-10 μg/ml) treated bladder cancer cells for 24 h, and showed significantly enhanced cytotoxicity and synergistic effect. Mapatumumab (100 ng/ml) does not activate T24 cells casapse-8, casapse-9 and casapse-3. [2] |
| In vivo | Mapatumumab (10 mg/kg intrperitoneally administered twice weekly for six weeks), two neuroblastoma xenotransplantation models (NB-1643 and NB-SD) showed excessive toxicity. [1] |
| Synonyms | HGS-ETR1, HGSETR1, HGS-1012, HGS1012, Anti-Human TNFRSF10A Recombinant Antibody |
| Cas No. | 658052-09-6 |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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