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Mapatumumab (Synonyms: HGS-ETR1, HGSETR1, HGS-1012, HGS1012, Anti-Human TNFRSF10A Recombinant Antibody)
Catalog No. T77371 Copy Product Info
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Mapatumumab (HGS-ETR1) is a fully human agonistic monoclonal antibody targeting TNF-related apoptosis-inducing ligand receptor 1, with anticancer activity, capable of inducing apoptosis in cancer cells.
Mapatumumab
Copy Product Info🥰Excellent
Catalog No. T77371
Synonyms HGS-ETR1, HGSETR1, HGS-1012, HGS1012, Anti-Human TNFRSF10A Recombinant Antibody
Mapatumumab (HGS-ETR1) is a fully human agonistic monoclonal antibody targeting TNF-related apoptosis-inducing ligand receptor 1, with anticancer activity, capable of inducing apoptosis in cancer cells.
Mapatumumab
Cas No. 658052-09-6
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $249 | - | In Stock | |
| 5 mg | $747 | - | In Stock | |
| 10 mg | $1,190 | - | In Stock | |
| 25 mg | $1,990 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:97.85% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Mapatumumab (HGS-ETR1) is a fully human agonistic monoclonal antibody targeting TNF-related apoptosis-inducing ligand receptor 1, with anticancer activity, capable of inducing apoptosis in cancer cells. |
| Targets&IC50 | TNFRSF10A/TRAILR1 (human):17.21 ng/mL (EC50) |
| In vitro | Mapatumumab (0.01-100 μg/mL) showed very limited activity against 23 cell lines of PPTP cultured in vitro, with no cell lines achieving 50% growth inhibition. [1] Mapatumumab (1-100 ng/ml) and EPI (0.1-10 μg/ml) treated bladder cancer cells for 24 h, and showed significantly enhanced cytotoxicity and synergistic effect. Mapatumumab (100 ng/ml) does not activate T24 cells casapse-8, casapse-9 and casapse-3. [2] |
| In vivo | Mapatumumab (10 mg/kg intrperitoneally administered twice weekly for six weeks), two neuroblastoma xenotransplantation models (NB-1643 and NB-SD) showed excessive toxicity. [1] |
| Synonyms | HGS-ETR1, HGSETR1, HGS-1012, HGS1012, Anti-Human TNFRSF10A Recombinant Antibody |
| Reactivity | Human |
| Verified Activity | Immobilized Human TNFRSF10A/TRAILR1/CD261 Protein (His) at 2 μg/mL can bind Mapatumumab. The EC50 is 0.01721 μg/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TNFRSF10A/TRAILR1/CD261 |
| Molecular Weight | 143.52 kDa |
| Cas No. | 658052-09-6 |
| Isotype | Human IgG2SA lambda2 |
| Recommended Isotype Control |
| Storage | -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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