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Rabeprazole sodium

Name: Rabeprazole sodium
Brand: TargetMol
SKU: T1651
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1651Cas No. 117976-90-6

Alias Rebeprazole sodium, LY307640 sodium, Habeprazole Sodium, Dexrabeprazole Sodium, Aciphex Sodium

Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exchanging ATPase which is found in gastric parietal cells.

Rabeprazole sodium

🥰Excellent

Purity: 99.912%

Catalog No. T1651Alias Rebeprazole sodium, LY307640 sodium, Habeprazole Sodium, Dexrabeprazole Sodium, Aciphex SodiumCas No. 117976-90-6

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$35	-	In Stock
25 mg	$61	-	In Stock
50 mg	$87	-	In Stock
100 mg	$123	-	In Stock
200 mg	$179	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.912%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exchanging ATPase which is found in gastric parietal cells.
Targets&IC50	UNH:0.3 μM (IC50)
In vitro	Administration of rabeprazole leads to a marked decrease in the viability of MKN-28 cells. Exposure to rabeprazole induces significant apoptosis in AGS cells. Rabeprazole completely inhibits the phosphorylation of ERK 1/2 in the MKN-28 cells, whereas the same effect is not observed in either the KATO III or MKN-45 cells. Rabeprazole is able to efficaciously inhibit the phosphorylation of ERK 1/2 in the gastric cancer cells.Thus, rabeprazole can attenuate the cell viability of human gastric cancer cells through inactivation of the ERK1/2 signaling pathway[2].
In vivo	Rabeprazole does not appear to exacerbate bone metabolic disorders in gastrectomized rats, but rather ameliorates the TG-induced BMD decrease[1].
Cell Research	Rabeprazole is administrated to three gastric cancer cell lines, KATO III, MKN-28 and MKN-45, at a dosage of 0.2 mM for 16 h. The viability of these cells is determined by a trypan blue exclusion assay.(Only for Reference)
Synonyms	Rebeprazole sodium, LY307640 sodium, Habeprazole Sodium, Dexrabeprazole Sodium, Aciphex Sodium

Chemical Properties

Molecular Weight	381.42
Formula	C₁₈H₂₀N₃NaO₃S
Cas No.	117976-90-6
Smiles	c12c([n-]c(n1)S(=O)Cc1c(c(ccn1)OCCCOC)C)cccc2.[Na+]
Relative Density.	0.45~0.55 g/ml
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 58.82 mg/mL (154.21 mM), Sonication is recommended.

H2O: 1.34 mg/mL (3.51 mM), Sonication is recommended.

Ethanol: 71 mg/mL (186.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.6218 mL	13.1089 mL	26.2178 mL	131.0891 mL

DMSO/Ethanol

	1mg	5mg	10mg	50mg
5 mM	0.5244 mL	2.6218 mL	5.2436 mL	26.2178 mL
10 mM	0.2622 mL	1.3109 mL	2.6218 mL	13.1089 mL
20 mM	0.1311 mL	0.6554 mL	1.3109 mL	6.5545 mL
50 mM	0.0524 mL	0.2622 mL	0.5244 mL	2.6218 mL
100 mM	0.0262 mL	0.1311 mL	0.2622 mL	1.3109 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc