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Daxdilimab
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Catalog No. T76767Cas No. 2245966-28-1
Alias VIB7734, MEDI7734
Daxdilimab (VIB7734) is a fully human monoclonal antibody targeting ILT7 (LILRA4), which is specifically expressed on plasmacytoid dendritic cells (pDCs). Daxdilimab depletes pDCs in circulation and tissues by inducing ADCC. As pDCs are the primary source of Type 1 interferons (IFN-I), this antibody effectively reduces IFN-I production and suppresses interferon-inducible gene signatures, serving as a tool for researching autoimmune diseases like SLE, dermatomyositis, and Sjögren's syndrome.
Daxdilimab
Daxdilimab
Copy Product Info😃Good
Catalog No. T76767Alias VIB7734, MEDI7734Cas No. 2245966-28-1
Daxdilimab (VIB7734) is a fully human monoclonal antibody targeting ILT7 (LILRA4), which is specifically expressed on plasmacytoid dendritic cells (pDCs). Daxdilimab depletes pDCs in circulation and tissues by inducing ADCC. As pDCs are the primary source of Type 1 interferons (IFN-I), this antibody effectively reduces IFN-I production and suppresses interferon-inducible gene signatures, serving as a tool for researching autoimmune diseases like SLE, dermatomyositis, and Sjögren's syndrome.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $173 | 2-4 weeks | 2-4 weeks | |
| 5 mg | $453 | 2-4 weeks | 2-4 weeks | |
| 10 mg | $738 | 2-4 weeks | 2-4 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Daxdilimab (VIB7734) is a fully human monoclonal antibody targeting ILT7 (LILRA4), which is specifically expressed on plasmacytoid dendritic cells (pDCs). Daxdilimab depletes pDCs in circulation and tissues by inducing ADCC. As pDCs are the primary source of Type 1 interferons (IFN-I), this antibody effectively reduces IFN-I production and suppresses interferon-inducible gene signatures, serving as a tool for researching autoimmune diseases like SLE, dermatomyositis, and Sjögren's syndrome. |
| In vitro | In biochemical assays, Daxdilimab binds to ILT7 on human pDCs. Functional assays show the antibody induces ADCC-mediated depletion of pDCs in PBMCs, leading to a significant reduction in IFN-alpha secretion following TLR agonist stimulation [1][2]. |
| In vivo | In humanized mouse or non-human primate models, systemic Daxdilimab (1-10 mg/kg) triggers rapid and sustained depletion of pDCs in blood and skin, significantly reducing the expression of interferon-stimulated genes (ISGs) [2]. |
| Synonyms | VIB7734, MEDI7734 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | IL-T7 |
| Cas No. | 2245966-28-1 |
| Isotype | IgG1-REM |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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