Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tofersen (BIIB067) is an antisense oligonucleotide utilized to inhibit the synthesis of superoxide dismutase 1 (SOD1) protein by facilitating the degradation of SOD1 mRNA via the RNase H-dependent mechanism. This compound holds potential for amyotrophic lateral sclerosis (ALS) research.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 623.00 |
Description | Tofersen (BIIB067) is an antisense oligonucleotide utilized to inhibit the synthesis of superoxide dismutase 1 (SOD1) protein by facilitating the degradation of SOD1 mRNA via the RNase H-dependent mechanism. This compound holds potential for amyotrophic lateral sclerosis (ALS) research. |
In vitro | Tofersen employs antisense oligonucleotides (ASOs) to specifically target SOD1 mRNA through Watson-Crick base pairing, facilitating the activation of RNase H1, which then degrades the targeted RNA[2]. |
Synonyms | BIIB067, ISIS-SOD1Rx |
Molecular Weight | N/A |
CAS No. | 2088232-70-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Tofersen 2088232-70-4 BIIB-067 BIIB 067 BIIB067 ISIS-SOD1Rx inhibitor inhibit