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Aegeline

🥰Excellent
Catalog No. T7846Cas No. 456-12-2

Aegeline is an alkaloidal-amide, isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.

Aegeline

Aegeline

🥰Excellent
Purity: 99.87%
Catalog No. T7846Cas No. 456-12-2
Aegeline is an alkaloidal-amide, isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 g$31In StockIn Stock
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.87%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Aegeline is an alkaloidal-amide, isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.
In vitro
Aegeline enhanced GLUT4 translocation mediated 2-deoxy-glucose uptake in both time and concentration-dependent manner.?2-deoxy-glucose uptake was completely stymied by the transport inhibitors (wortmannin and genistein) in C2C12 myotubes.?Pharmacological inhibition of Akt (also known as protein kinase B) and Ras-related C3 botulinum toxin substrate 1 (Rac1) suggest that both Akt and Rac1 operate aegeline-stimulated glucose transport via distinct parallel pathways.?Moreover, aegeline activates p21 protein-activated kinase 1 (PAK1) and cofilin (an actin polymerization regulator).?Rac1 inhibitor (Rac1 inhib II) and PAK1 inhibitor (IPA-3) completely blocked aegeline-induced phosphorylation of cofilin and p21 protein-activated kinase 1 (PAK1)[1].
Chemical Properties
Molecular Weight297.35
FormulaC18H19NO3
Cas No.456-12-2
SmilesCOc1ccc(cc1)C(O)CNC(=O)\C=C\c1ccccc1
Relative Density.1.178 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 25 mg/mL (84.08 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3630 mL16.8152 mL33.6304 mL168.1520 mL
5 mM0.6726 mL3.3630 mL6.7261 mL33.6304 mL
10 mM0.3363 mL1.6815 mL3.3630 mL16.8152 mL
20 mM0.1682 mL0.8408 mL1.6815 mL8.4076 mL
50 mM0.0673 mL0.3363 mL0.6726 mL3.3630 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

αsynyeasttoxicitySNARESec22pproteinInhibitorinhibitFungalAegeline
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