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Aclacinomycin A

Name: Aclacinomycin A
Brand: TargetMol
SKU: T21502
Price: 299 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21502Cas No. 57576-44-0

Alias Aclarubicin

Aclacinomycin A (Aclarubicin) is a novel anthracycline antibiotic isolated from Streptomyces galilei with antitumor activity.Aclacinomycin A is an inhibitor of topoisomerases I and II and inhibits RNA activity.Aclacinomycin A has been used in the study of relapsed leukemia and advanced malignant lymphomas.

Aclacinomycin A

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Purity: 99.43%

Catalog No. T21502Alias AclarubicinCas No. 57576-44-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$299	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.43%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Aclacinomycin A (Aclarubicin) is a novel anthracycline antibiotic isolated from Streptomyces galilei with antitumor activity.Aclacinomycin A is an inhibitor of topoisomerases I and II and inhibits RNA activity.Aclacinomycin A has been used in the study of relapsed leukemia and advanced malignant lymphomas.
In vitro	In V79 and irs-2 cells, Aclacinomycin A (0, 0.006, 0.12, 1.2, and 2.4 μM; 3 hours) inhibited the catalytic activity of topoisomerase II in a dose-dependent manner. The loss of topoisomerase II catalytic activity in Aclacinomycin A-treated cells was significant in all cases compared to untreated cells[2].
In vivo	In DBA/2 and CDF1 (BALB/c×DBA/2) mice weighing 90-110 g with leukemia P-388 model, Aclacinomycin A (0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg; intraperitoneal administration daily for 10 days starting 3 hr after transplantation) inhibited tumor growth[4].
Synonyms	Aclarubicin

Chemical Properties

Molecular Weight	811.87
Formula	C₄₂H₅₃NO₁₅
Cas No.	57576-44-0
Smiles	C(OC)(=O)[C@@H]1C2=C([C@@H](O[C@H]3C[C@H](N(C)C)[C@H](O[C@H]4C[C@H](O)[C@H](O[C@@H]5O[C@@H](C)C(=O)CC5)[C@H](C)O4)[C@H](C)O3)C[C@@]1(CC)O)C(O)=C6C(=C2)C(=O)C=7C(C6=O)=C(O)C=CC7
Relative Density.	1.42 g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (36.95 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2317 mL	6.1586 mL	12.3172 mL	61.5862 mL
5 mM	0.2463 mL	1.2317 mL	2.4634 mL	12.3172 mL
10 mM	0.1232 mL	0.6159 mL	1.2317 mL	6.1586 mL
20 mM	0.0616 mL	0.3079 mL	0.6159 mL	3.0793 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc