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Aclacinomycin A

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Catalog No. T21502Cas No. 57576-44-0
Alias Aclarubicin

Aclacinomycin A (Aclarubicin) is a novel anthracycline antibiotic isolated from Streptomyces galilei with antitumor activity.Aclacinomycin A is an inhibitor of topoisomerases I and II and inhibits RNA activity.Aclacinomycin A has been used in the study of relapsed leukemia and advanced malignant lymphomas.

Aclacinomycin A
Other Forms of Aclacinomycin A:
Aclacinomycin A hydrochlorideT1023875443-99-1
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Aclacinomycin A

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Purity: 99.43%
Catalog No. T21502Alias AclarubicinCas No. 57576-44-0
Aclacinomycin A (Aclarubicin) is a novel anthracycline antibiotic isolated from Streptomyces galilei with antitumor activity.Aclacinomycin A is an inhibitor of topoisomerases I and II and inhibits RNA activity.Aclacinomycin A has been used in the study of relapsed leukemia and advanced malignant lymphomas.
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1 mg$299In Stock
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Purity:99.43%
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Product Introduction

Bioactivity
Description
Aclacinomycin A (Aclarubicin) is a novel anthracycline antibiotic isolated from Streptomyces galilei with antitumor activity.Aclacinomycin A is an inhibitor of topoisomerases I and II and inhibits RNA activity.Aclacinomycin A has been used in the study of relapsed leukemia and advanced malignant lymphomas.
In vitro
In V79 and irs-2 cells, Aclacinomycin A (0, 0.006, 0.12, 1.2, and 2.4 μM; 3 hours) inhibited the catalytic activity of topoisomerase II in a dose-dependent manner. The loss of topoisomerase II catalytic activity in Aclacinomycin A-treated cells was significant in all cases compared to untreated cells[2].
In vivo
In DBA/2 and CDF1 (BALB/c×DBA/2) mice weighing 90-110 g with leukemia P-388 model, Aclacinomycin A (0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg; intraperitoneal administration daily for 10 days starting 3 hr after transplantation) inhibited tumor growth[4].
SynonymsAclarubicin
Chemical Properties
Molecular Weight811.87
FormulaC42H53NO15
Cas No.57576-44-0
SmilesC(OC)(=O)[C@@H]1C2=C([C@@H](O[C@H]3C[C@H](N(C)C)[C@H](O[C@H]4C[C@H](O)[C@H](O[C@@H]5O[C@@H](C)C(=O)CC5)[C@H](C)O4)[C@H](C)O3)C[C@@]1(CC)O)C(O)=C6C(=C2)C(=O)C=7C(C6=O)=C(O)C=CC7
Relative Density.1.42 g/cm3
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30 mg/mL (36.95 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.2317 mL6.1586 mL12.3172 mL61.5862 mL
5 mM0.2463 mL1.2317 mL2.4634 mL12.3172 mL
10 mM0.1232 mL0.6159 mL1.2317 mL6.1586 mL
20 mM0.0616 mL0.3079 mL0.6159 mL3.0793 mL

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Keywords

Topo IITopo IRNA
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