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KPC-2-IN-2 (Compound 6c) is a potent Klebsiella pneumoniae carbapenemase (KPC-2) inhibitor with a Ki of 0.038 μM and can enhance the activity of cefotaxime in E. coli expressing KPC-2 [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 10-14 weeks | 10-14 weeks | |
| 50 mg | $1,980 | 10-14 weeks | 10-14 weeks | |
| 100 mg | $2,500 | 10-14 weeks | 10-14 weeks |
| Description | KPC-2-IN-2 (Compound 6c) is a potent Klebsiella pneumoniae carbapenemase (KPC-2) inhibitor with a Ki of 0.038 μM and can enhance the activity of cefotaxime in E. coli expressing KPC-2 [1]. |
| In vitro | KPC-2-IN-2 treatment, at concentrations of 5 and 50 μg/mL for a 24-hour period, demonstrates remarkable tolerance in HEK-293 cells, as evidenced by a Cell Cytotoxicity Assay. Specifically, the assay results indicate that the cells retain over 80% viability after 24 hours, both with and without the co-presence of 30 μg/mL cefotaxime. |
| Molecular Weight | 271.1 |
| Formula | C12H10BN3O2S |
| Smiles | #N/A |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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