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2,2′-Dipyridyl disulfide

Name: 2,2′-Dipyridyl disulfide
Brand: TargetMol
SKU: T19780
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19780Cas No. 2127-03-9

Alias Orthopyridyl disulfide, OPSS, Aldrithiol 2, 2,2'-Dipyridyl disulfide

2,2′-Dipyridyl disulfide (Aldrithiol 2) is a useful reagent for the determination of sulfhydryl groups. It acts as a peptide coupling reagent and as an oxidizing agent. 2,2′-Dipyridyl disulfide (Aldrithiol 2) is also used for the activation of glycosides.

2,2′-Dipyridyl disulfide

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Purity: 99.84%

Catalog No. T19780Alias Orthopyridyl disulfide, OPSS, Aldrithiol 2, 2,2'-Dipyridyl disulfideCas No. 2127-03-9

Pack Size	Price	USA Warehouse	Global Warehouse
2 g	$33	-	In Stock
5 g	$52	-	In Stock
10 g	$85	-	In Stock
25 g	$158	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.84%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

2,2′-Dipyridyl disulfide AI Summary

2,2′-Dipyridyl disulfide is a versatile inhibitor that demonstrates significant bioactivity across various targets. In a proliferating human T-cell line, it effectively inhibits the replication of HIV-1 with an IC50 value of 55.1 nM as measured by an XTT assay. It possesses antiviral activity against HIV-1 in HEK293T cells, showing a fold change (FC) greater than 4.0 at a concentration of 1 mM after 1 hour. Additionally, 2,2′-Dipyridyl disulfide inhibits the ATPase activity of Tag (IC50 > 25000 nM), JMJD2A-Tudor Domain (IC50 = 3981.1 nM), Plasmodium falciparum Glucose-6-phosphate dehydrogenase (IC50 = 9820.0 nM), APOBEC3G DNA Deaminase (IC50 = 3880.0 nM), and WRN Helicase (IC50 = 22387.2 nM). It also induces DNA re-replication in MCF 10a normal breast cells with a potency of 29092.9 nM, acts as a potential activator for Integrin-Mediated Alleviation for Muscular Dystrophy (10000 nM), and is a candidate inhibitor for Trypanosoma Brucei (25118.9 nM). Furthermore, it inhibits PLK1-PDB (polo-like kinase 1 - polo-box domain) with an IC50 of 670.2 nM and demonstrates strong inhibition of human histone lysine methyltransferases, GLP and G9a, with IC50 values of 2700.0 nM and 650.0 nM, respectively, at 100 µM concentration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2,2′-Dipyridyl disulfide (Aldrithiol 2) is a useful reagent for the determination of sulfhydryl groups. It acts as a peptide coupling reagent and as an oxidizing agent. 2,2′-Dipyridyl disulfide (Aldrithiol 2) is also used for the activation of glycosides.
Synonyms	Orthopyridyl disulfide, OPSS, Aldrithiol 2, 2,2'-Dipyridyl disulfide

Chemical Properties

Molecular Weight	220.31
Formula	C₁₀H₈N₂S₂
Cas No.	2127-03-9
Smiles	S(Sc1ccccn1)c1ccccn1
Relative Density.	1.34g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (249.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.08 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5391 mL	22.6953 mL	45.3906 mL	226.9529 mL
5 mM	0.9078 mL	4.5391 mL	9.0781 mL	45.3906 mL
10 mM	0.4539 mL	2.2695 mL	4.5391 mL	22.6953 mL
20 mM	0.2270 mL	1.1348 mL	2.2695 mL	11.3476 mL
50 mM	0.0908 mL	0.4539 mL	0.9078 mL	4.5391 mL
100 mM	0.0454 mL	0.2270 mL	0.4539 mL	2.2695 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc