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Etofibrate

Name: Etofibrate
Brand: TargetMol
SKU: T2554
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2554Cas No. 31637-97-5

Etofibrate is a combination of clofibrate and niacin, used to treat hyperlipemia.

Etofibrate

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Purity: 98.74%

Catalog No. T2554Cas No. 31637-97-5

Etofibrate is a combination of clofibrate and niacin, used to treat hyperlipemia.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$39	In Stock	In Stock
50 mg	$49	In Stock	In Stock
100 mg	$78	In Stock	In Stock
200 mg	$119	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.74%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Etofibrate is a combination of clofibrate and niacin, used to treat hyperlipemia.
In vitro	Administering 200 mg/kg of Etofibrate results in significant inhibition of neointimal proliferation of smooth muscle cells in a rabbit model of atherosclerosis, leading to less pronounced plaque expansion. Additionally, 1.2 mM/g of Etofibrate lowers plasma free fatty acid (FFA) levels in male Sprague-Dawley rats. The effect of Etofibrate on plasma glycerol levels varies depending on the dosage and duration of treatment, either increasing or decreasing these levels.
In vivo	Etofibrate significantly reduces the concentration of cholesterol, triglycerides, free fatty acids, and glycerol, in both total and unesterified forms, in the microsomal fraction of rat liver plasma. It increases the activity of glycerol-3-phosphate dehydrogenase in hepatocytes, which leads to a reduction in the activities of microsomal HMG-CoA reductase and cholesterol 7α-hydroxylase without affecting acyl CoA: cholesterol acyltransferase. Moreover, etofibrate boosts the activity of cytosolic glyceraldehyde-3-phosphate dehydrogenase and the overall concentration of carnitine in rat liver, consequently lowering the concentrations of triglycerides and cholesterol. When fed rats' epididymal adipose tissue is cultured under basal conditions, etofibrate stimulates the rate of fatty acid re-esterification. It reduces the action of lipolytic products in the liver by releasing lipolytic products from adipose tissue and through intrinsic liver metabolism.

Chemical Properties

Molecular Weight	363.79
Formula	C₁₈H₁₈ClNO₅
Cas No.	31637-97-5
Smiles	CC(C)(Oc1ccc(Cl)cc1)C(=O)OCCOC(=O)c1cccnc1
Relative Density.	1.2303 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 68 mg/mL (186.92 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 68 mg/mL (186.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.7488 mL	13.7442 mL	27.4884 mL	137.4419 mL
5 mM	0.5498 mL	2.7488 mL	5.4977 mL	27.4884 mL
10 mM	0.2749 mL	1.3744 mL	2.7488 mL	13.7442 mL
20 mM	0.1374 mL	0.6872 mL	1.3744 mL	6.8721 mL
50 mM	0.0550 mL	0.2749 mL	0.5498 mL	2.7488 mL
100 mM	0.0275 mL	0.1374 mL	0.2749 mL	1.3744 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc