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Anti-GPCR GPR75 Polyclonal Antibody

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Catalog No. TMAB-06659

Anti-GPCR GPR75 Polyclonal Antibody is a Rabbit antibody targeting GPCR GPR75. Anti-GPCR GPR75 Polyclonal Antibody can be used in WB.

Anti-GPCR GPR75 Polyclonal Antibody

Anti-GPCR GPR75 Polyclonal Antibody

😃Good
Catalog No. TMAB-06659
Anti-GPCR GPR75 Polyclonal Antibody is a Rabbit antibody targeting GPCR GPR75. Anti-GPCR GPR75 Polyclonal Antibody can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2217-10 days7-10 days
100 μL$3727-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-GPCR GPR75 Polyclonal Antibody is a Rabbit antibody targeting GPCR GPR75. Anti-GPCR GPR75 Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Mouse (predicted:Human)
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCell membrane; Multipass membrane protein.
Tissue SpecificityExpressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe two G protein-coupled receptors GPR7 and GPR8 display high similarity to each other. They both show high expression in brain and in particular in hypothalamus, and have been characterized as receptors for neuropeptide W (NPW) and neuropeptide B (NPB). In response to NPW and NPB, they play a role in the regulation of feeding behavior. GPR7 deficient mice develop an adult-onset obese phenotype that progressively worsens with age and is exacerbated when fed a high-fat diet. The genes encoding human GPR7 and GPR8 map to chromosomes 10q11.2-q21.1 and 10q13.3, respectively.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human GPCR GPR75
Antigen Species
Human
Gene Name
GPR75
Gene ID
Protein Name
Probable G-protein coupled receptor 75
Uniprot ID
Function
GPR7 interacts specifically with a number of opioid ligands. It is a receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals, and has a higher affinity for neuropeptide B. It has been reported in brain, mainly cerebellum and frontal cortex, and in the pituitary (O'Dowd et al., 1995). The mouse ortholog of GPR7 was shown by in situ hybridization to be expressed in discrete nuclei of brain, namely suprachiasmatic, arcuate, and ventromedial nuclei of hypothalamus.
Chemical Properties
Molecular WeightTheoretical: 59 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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