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Anti-DPP4/CD26 Antibody-APC (7W775)

🥰Excellent
Catalog No. TMAY-03429A

Anti-DPP4/CD26 Antibody-APC (7W775) is a APC-conjugated Rabbit antibody targeting DPP4/CD26. Anti-DPP4/CD26 Antibody-APC (7W775) can be used in FCM.

Anti-DPP4/CD26 Antibody-APC (7W775)

Anti-DPP4/CD26 Antibody-APC (7W775)

🥰Excellent
Catalog No. TMAY-03429A
Anti-DPP4/CD26 Antibody-APC (7W775) is a APC-conjugated Rabbit antibody targeting DPP4/CD26. Anti-DPP4/CD26 Antibody-APC (7W775) can be used in FCM.
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Product Introduction

Bioactivity
Description
Anti-DPP4/CD26 Antibody-APC (7W775) is a APC-conjugated Rabbit antibody targeting DPP4/CD26. Anti-DPP4/CD26 Antibody-APC (7W775) can be used in FCM.
Ig Type
Monoclonal Rabbit IgG
Clone
7W775
Reactivity
Mouse
Verified Activity
Flow cytometric analysis of Mouse DPP4(CD26) expression on BABL/c splenocytes. Cells were stained with APC-conjugated anti-Mouse DPP4(CD26). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Application
FCM
Recommended Dose
5 μl/Test, 0.1 mg/ml
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Mouse DPP4 / CD26 (rM DPP4 / CD26; TMPY-00074; NP_034204.1; Ser29-His760) and conjugated with APC under optimum conditions, the unreacted APC was removed.
PurificationProtein A
AppearanceLiquid
FormulationPBS solution containing 0.5% BSA and 0.09% sodium azide
Research BackgroundDipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides, and peptide hormones. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). The soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. As both a regulatory enzyme and a signalling factor, DPP4 has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). This causes an increase in glucose-dependent stimulation, resulting in a lowering of blood glucose levels. Recent studies have shown that DPP4 inhibitors can induce a significant reduction in glycosylated haemoglobin (HbA(1c)) levels, either as monotherapy or as a combination with other antidiabetic agents. Research has also demonstrated that DPP4 inhibitors portray a very low risk of hypoglycaemia development, and are a new pharmacological class of drugs for treating Type 2 diabetes.
Related Conjugates and Formulations
Conjucates
APC
Others Formats
Unconjugated/FITC/PE
Antibody Types Available
4
Antigen Details
Immunogen
Recombinant Mouse DPP4 / CD26 Protein (TMPY-00074)
Antigen Species
Mouse
Biology Area
Serine Proteases and Regulators
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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