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Zoledronic Acid

Name: Zoledronic Acid
Brand: TargetMol
SKU: T6739
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6739Cas No. 118072-93-8

Alias Zometa, Zoledronate, ZOL 446, CGP42446A, CGP 42446

Zoledronic Acid (ZOL 446) is a bisphosphonate. Zoledronic Acid (ZOL 446) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalcemia of malignancy and can be helpful for treating pain from bone metastases. An annual dose of Zoledronate may also prevent recurring fractures in patients with a previous hip fracture. Zoledronic Acid (ZOL 446) is a single 5 mg infusion for the treatment of Paget's disease of bone. In 2007, the FDA also approved Reclast for the treatment of postmenopausal osteoporosis.

Zoledronic Acid

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Purity: 99.93%

Catalog No. T6739Alias Zometa, Zoledronate, ZOL 446, CGP42446A, CGP 42446Cas No. 118072-93-8

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$32	In Stock	In Stock
25 mg	$47	In Stock	In Stock
50 mg	$77	In Stock	In Stock
100 mg	$127	In Stock	In Stock
200 mg	$188	In Stock	In Stock
500 mg	$317	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.93%

Color:White

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Product Introduction

Bioactivity

Description	Zoledronic Acid (ZOL 446) is a bisphosphonate. Zoledronic Acid (ZOL 446) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalcemia of malignancy and can be helpful for treating pain from bone metastases. An annual dose of Zoledronate may also prevent recurring fractures in patients with a previous hip fracture. Zoledronic Acid (ZOL 446) is a single 5 mg infusion for the treatment of Paget's disease of bone. In 2007, the FDA also approved Reclast for the treatment of postmenopausal osteoporosis.
In vitro	Zoledronic acid (120 mg/kg, subcutaneously) prevented damage formation, prevented cancellous bone loss and loss of bone mineral density, and reduced osteoclast circumference in 5T2 mM mice, also decreasing paraprotein concentration and tumor load, and reducing angiogenesis.
In vivo	Zoledronic acid (120 mg/kg, subcutaneously) prevented damage formation, prevented cancellous bone loss and loss of bone mineral density, and reduced osteoclast circumference in 5T2 mM mice, also decreasing paraprotein concentration and tumor load, and reducing angiogenesis.
Synonyms	Zometa, Zoledronate, ZOL 446, CGP42446A, CGP 42446

Chemical Properties

Molecular Weight	272.09
Formula	C₅H₁₀N₂O₇P₂
Cas No.	118072-93-8
Smiles	C(P(=O)(O)O)(P(=O)(O)O)(CN1C=CN=C1)O
Relative Density.	2.13 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 1.6 mg/mL (5.88 mM), Sonication is recommended.

DMSO: < 1 mg/mL (insoluble or slightly soluble)

0.1M NAOH: 12.5 mg/mL (45.94 mM), Sonication is recommended.

Solution Preparation Table

H2O/0.1M NAOH

	1mg	5mg	10mg	50mg
1 mM	3.6753 mL	18.3763 mL	36.7525 mL	183.7627 mL
5 mM	0.7351 mL	3.6753 mL	7.3505 mL	36.7525 mL

0.1M NAOH

	1mg	5mg	10mg	50mg
10 mM	0.3675 mL	1.8376 mL	3.6753 mL	18.3763 mL
20 mM	0.1838 mL	0.9188 mL	1.8376 mL	9.1881 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc