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RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $39 | In Stock | |
2 mg | $55 | In Stock | |
5 mg | $89 | In Stock | |
10 mg | $147 | In Stock | |
25 mg | $278 | In Stock | |
50 mg | $419 | In Stock | |
100 mg | $587 | In Stock |
Description | RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6. |
Targets&IC50 | GSK-3β:3 nM, CDK5-p35:5 nM, Cyclin E-CDK2:3 nM, AMPK:41 nM, c-Src:25 nM, Cyclin B1-CDK1:2 nM, CDK7-CyclinH:44 nM, Cyclin D1-CDK4:4 nM, MEK1:54 nM, Cyclin T1-CDK9:1 nM, TAK1:5 nM, JNK1a1:17 nM, JAK2:50 nM, CDK6-CyclinD3:55 nM, JNK1a2:40 nM, Cyclin E-CDK3:5 nM |
Molecular Weight | 545.63 |
Formula | C29H35N7O4 |
Cas No. | 784210-88-4 |
Smiles | COCCN1CCN(Cc2ccc(cc2)-c2n[nH]c3-c4cccc(NC(=O)NN5CCOCC5)c4C(=O)c23)CC1 |
Relative Density. | 1.39 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Solubility Information | DMSO: Slightly soluble ![]() |
In Vivo Formulation | 15% Solutol HS-15 in Saline: 10 mg/mL (18.33 mM), Suspension. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.![]() |
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