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Anti-Cathepsin D Polyclonal Antibody

Catalog No. TMAB-03684 Copy Product Info
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Anti-Cathepsin D Polyclonal Antibody is a Rabbit antibody targeting Cathepsin D. Anti-Cathepsin D Polyclonal Antibody can be used in WB.

Anti-Cathepsin D Polyclonal Antibody

Copy Product Info
🥰Excellent
Catalog No. TMAB-03684

Anti-Cathepsin D Polyclonal Antibody is a Rabbit antibody targeting Cathepsin D. Anti-Cathepsin D Polyclonal Antibody can be used in WB.

Anti-Cathepsin D Polyclonal Antibody
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2227-10 days7-10 days
100 μL$3747-10 days7-10 days
200 μL$5297-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-Cathepsin D Polyclonal Antibody is a Rabbit antibody targeting Cathepsin D. Anti-Cathepsin D Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Rat (predicted:Human,Mouse,Dog,Pig,Cow,Rabbit)
Verified Activity
Sample:
Lane 1: Rat Liver tissue lysates
Lane 2: Rat Small intestine tissue lysates
Primary: Anti-Cathepsin D (TMAB-03684) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 11/38/45 kDa
Observed band size: 46 kDa
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationLysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue SpecificityExpressed in the aorta extrcellular space (at protein level).
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundCathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer and possibly Alzheimer's disease.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human Cathepsin D light chain
Antigen Species
Human
Gene Name
CTSD
Gene ID
1509
Protein Name
Cathepsin D
Uniprot ID
P07339
Function
Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Chemical Properties
Molecular WeightTheoretical: 11/38/45 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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