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Glutaric acid

Name: Glutaric acid
Brand: TargetMol
SKU: T4794
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4794Cas No. 110-94-1

Glutaric acid is a simple five-carbon linear dicarboxylic acid. Glutaric acid is naturally produced in the body during the metabolism of some amino acids, including lysine and tryptophan

Glutaric acid

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Purity: 98.83%

Catalog No. T4794Cas No. 110-94-1

Glutaric acid is a simple five-carbon linear dicarboxylic acid. Glutaric acid is naturally produced in the body during the metabolism of some amino acids, including lysine and tryptophan

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.83%

Appearance:Solid

Color:White

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COA GC HNMR LCMS

Product Introduction

Bioactivity

Description

Glutaric acid is a simple five-carbon linear dicarboxylic acid. Glutaric acid is naturally produced in the body during the metabolism of some amino acids, including lysine and tryptophan

In vitro

Glutaric acid, at concentrations of 1 and 2 mM, significantly reduces TRAP measurement by up to 28%, showcasing a dose-dependent efficacy (β=0.77; P<0.001). Additionally, a strong inverse correlation is observed between chemiluminescence and TRAP levels (β=0.81; P<0.001), indicating glutaric acid's potential impact on these parameters. Despite not affecting the activities of catalase (Cat) and superoxide dismutase (SOD), glutaric acid notably inhibits glutathione peroxidase (GPx) activity by up to 46%, starting at a minimal concentration of 0.5 mM. This inhibition is further confirmed to follow a dose-dependent pattern, beginning from concentrations as low as 0.05 mM[2], underscoring its potent and variable effect based on the dosage administered.

Chemical Properties

Molecular Weight	132.11
Formula	C₅H₈O₄
Cas No.	110-94-1
Smiles	C(CC(O)=O)CC(O)=O
Relative Density.	1.429 dimensionless. Temperature:15 °C.;1.429 g/cm3. Temperature:15 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: Soluble

DMSO: 55 mg/mL (416.32 mM), Sonication is recommended.

H2O: 5 mg/mL (37.85 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (15.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	7.5694 mL	37.8472 mL	75.6945 mL	378.4725 mL
5 mM	1.5139 mL	7.5694 mL	15.1389 mL	75.6945 mL
10 mM	0.7569 mL	3.7847 mL	7.5694 mL	37.8472 mL
20 mM	0.3785 mL	1.8924 mL	3.7847 mL	18.9236 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.1514 mL	0.7569 mL	1.5139 mL	7.5694 mL
100 mM	0.0757 mL	0.3785 mL	0.7569 mL	3.7847 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc