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Bakuchiol

Name: Bakuchiol
Brand: TargetMol
SKU: T3400
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3400Cas No. 10309-37-2

Bakuchiol possesses anti-tumor,and anti-helmenthic properties. It has cytotoxic activity, mainly due to its DNA polymerase1 inhibiting activity. Bakuchiol has anti-bacterial activity against oral pathogens, has great potential for use in food additives and mouthwash for preventing and treating dental caries.

Bakuchiol

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Purity: 99.05%

Catalog No. T3400Cas No. 10309-37-2

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	-	In Stock
10 mg	$57	In Stock	In Stock
25 mg	$90	In Stock	In Stock
50 mg	$128	-	In Stock
100 mg	$189	-	In Stock
500 mg	$468	-	In Stock
1 mL x 10 mM (in DMSO)	$44	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.05%

Color:Yellow

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bakuchiol AI Summary

Bakuchiol exhibits a broad spectrum of biological activities. It demonstrates significant antibacterial activity, notably against Staphylococcus aureus and Methicillin-resistant Staphylococcus aureus strains, with MIC values ranging from 3.125 to 19,000.0 nM, and shows notable efficacy against oral bacteria, with MIC values from 1.0 to 32.0 ug/mL. However, it exhibits lower activity against Escherichia coli and Pseudomonas aeruginosa with MIC values greater than 780,000.0 nM. Furthermore, the compound demonstrates inhibitory effects on biofilm formation by Streptococcus mutans (MBIC50 = 4.0 ug/mL). Bakuchiol also displays antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells. It has shown potential as an inhibitor of SARS-CoV-2 3CL-Pro protease at 20 μM. Additionally, it exerts inhibitory effects on hypoxia-induced HIF1 activation and TNF-alpha-induced NF-kappaB activation in human cells with IC50 values of 6100.0 nM and 6900.0 nM, respectively. In cancer research, Bakuchiol exhibits cytotoxicity against multiple cell lines, including AGS, HeLa, MDA-MB-231, and T47D cells, with IC50 values ranging from 11,000.0 nM to 82,900.0 nM. It also shows growth inhibition across a variety of tumor cell lines with GI50 values from 10,000 nM to 22,000 nM. The compound inhibits T and B cell proliferation and displays antimutagenic activity in Salmonella Typhimurium T98. Moreover, Bakuchiol exhibits cholinesterase inhibition, having slight effects on electric eel AChE (-7.92%) and more significant inhibition on horse BChE (13.38%) at 2 mg/ml. It also induces DNA damage in human SU8686 cells and inhibits human HDAC6 enzyme activity with varied inhibition percentages depending on the substrate used. Lastly, Bakuchiol demonstrates moderate cytotoxicity against RAW 264.7 cells (IC50 = 97,230.0 nM) and shows lower cytotoxicity against HepG2, Raji, Jurkat, BJ, and HEK293 cells at higher concentrations. These diverse activities indicate its potential for therapeutic applications across antibacterial, antiviral, antitumor, and other biomedical research areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	256.38
Formula	C₁₈H₂₄O
Cas No.	10309-37-2
Smiles	CC(C)=CCC[C@@](C)(C=C)\C=C\c1ccc(O)cc1
Relative Density.	0.963 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (253.53 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.: Soluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9005 mL	19.5023 mL	39.0046 mL	195.0230 mL
5 mM	0.7801 mL	3.9005 mL	7.8009 mL	39.0046 mL
10 mM	0.3900 mL	1.9502 mL	3.9005 mL	19.5023 mL
20 mM	0.1950 mL	0.9751 mL	1.9502 mL	9.7512 mL
50 mM	0.0780 mL	0.3900 mL	0.7801 mL	3.9005 mL
100 mM	0.0390 mL	0.1950 mL	0.3900 mL	1.9502 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc