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Flusilazole

Name: Flusilazole
Brand: TargetMol
SKU: T20835
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20835Cas No. 85509-19-9

Alias Sanction, Olymp, Nustar, Flusilazol, DPX-6573, DPX6573

Flusilazole (DPX6573) is an organosilicon fungicide with broad spectrum antifungal effects. Flusilazole can be used to control fungal infections on a variety of vegetables and fruits.

Flusilazole

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Purity: 99.64%

Catalog No. T20835Alias Sanction, Olymp, Nustar, Flusilazol, DPX-6573, DPX6573Cas No. 85509-19-9

Flusilazole (DPX6573) is an organosilicon fungicide with broad spectrum antifungal effects. Flusilazole can be used to control fungal infections on a variety of vegetables and fruits.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.64%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Flusilazole AI Summary

Flusilazole is a bioactive molecule with significant impacts on various signaling pathways and notable antifungal properties. It functions as an agonist of retinoid X receptor alpha, peroxisome proliferator-activated receptor delta, rat pregnane X receptor, and human pregnane X receptor signaling pathways, and as an antagonist of farnesoid X receptor and retinoid X receptor alpha signaling, with potencies ranging from 7943.3 nM to 31622.8 nM. In agricultural applications, Flusilazole demonstrates considerable in vivo antifungal activity. Pre-treatment with 2 µg/ml led to a 78.0% reduction in wheat leaf rust caused by Puccinia recondita, with complete control at 10 µg/ml. It also significantly reduces the disease index of cucumber infected with Cladosporium cucumerinum by 95.56% when applied as a 40% SC formulation. Additionally, Flusilazole shows potent fungicidal activity against several fungal species, including Diplodia mutila, Neofusicoccum luteum, Leptosphaeria biglobosa, Leptosphaeria maculans, Oculimacula yallundae, and Oculimacula acuformis, effectively inhibiting mycelial growth, conidial germination, and ascospore germination at low concentrations. For example, it achieves significant inhibition of mycelial growth in Leptosphaeria biglobosa and Leptosphaeria maculans with ED50 values of 0.67 µg/ml and 0.27 µg/ml, respectively. It also inhibits pathogen activity in Neofusicoccum luteum infected Pinot noir grapevines, and demonstrates fungitoxicity against Monilinia laxa strains with EC50 values ranging from 0.1 to 0.4 µg/ml. When applied to plant foliage at 20 ppm, Flusilazole achieves high disease control efficacies of 99.0% against Phaeosphaeria nodorum and 98.0% against Oculimacula yallundae. Its efficacy also extends to prochloraz-resistant isolates of Oculimacula spp., showcasing its potential as a broad-spectrum antifungal agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Flusilazole (DPX6573) is an organosilicon fungicide with broad spectrum antifungal effects. Flusilazole can be used to control fungal infections on a variety of vegetables and fruits.
Synonyms	Sanction, Olymp, Nustar, Flusilazol, DPX-6573, DPX6573

Chemical Properties

Molecular Weight	315.39
Formula	C₁₆H₁₅F₂N₃Si
Cas No.	85509-19-9
Smiles	C[Si](Cn1cncn1)(c1ccc(F)cc1)c1ccc(F)cc1
Relative Density.	1.17 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (301.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1707 mL	15.8534 mL	31.7068 mL	158.5339 mL
5 mM	0.6341 mL	3.1707 mL	6.3414 mL	31.7068 mL
10 mM	0.3171 mL	1.5853 mL	3.1707 mL	15.8534 mL
20 mM	0.1585 mL	0.7927 mL	1.5853 mL	7.9267 mL
50 mM	0.0634 mL	0.3171 mL	0.6341 mL	3.1707 mL
100 mM	0.0317 mL	0.1585 mL	0.3171 mL	1.5853 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc