Shopping Cart

Your shopping cart is currently empty

PTP Inhibitor IV

Name: PTP Inhibitor IV
Brand: TargetMol
SKU: T22137
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T22137Cas No. 329317-98-8

PTP Inhibitor IV is an effective protein tyrosine phosphatase (PTP) inhibitor, which can selectively inhibit DUSP14 phosphatase activity (IC50.5.21μm). PTP Inhibitor IV inhibited SHP-2, PTP1B, PTp-ε, PTP Meg-2, PTP-σ, PTP-β and PTP-μ, IC50 were 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively. PTP Inhibitor IV affects cellular signaling by inhibiting PTP activity and may regulate specific pathways associated with PTP-mediated signaling events.

PTP Inhibitor IV

Copy Product Info

😃Good

Purity: 99.76%

Catalog No. T22137Cas No. 329317-98-8

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$38	In Stock	In Stock
10 mg	$59	In Stock	In Stock
25 mg	$136	In Stock	In Stock
50 mg	$220	In Stock	In Stock
100 mg	$355	-	In Stock
200 mg	$490	-	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.76%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PTP Inhibitor IV is an effective protein tyrosine phosphatase (PTP) inhibitor, which can selectively inhibit DUSP14 phosphatase activity (IC50.5.21μm). PTP Inhibitor IV inhibited SHP-2, PTP1B, PTp-ε, PTP Meg-2, PTP-σ, PTP-β and PTP-μ, IC50 were 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively. PTP Inhibitor IV affects cellular signaling by inhibiting PTP activity and may regulate specific pathways associated with PTP-mediated signaling events.
Targets&IC50	PTP1B:2.5 μM, PTPσ:20 μM, PTPμ:6.7 μM, PTP Meg2:13 μM, PTPβ:6.4 μM, DUSP14:5.21 μM, SHP2:1.8 μM, PTPε:8.4 μM
In vitro	PTP Inhibitor IV downregulates the catalytic activity of DUSP14 by binding at the catalytic site.[1] PTP Inhibitor IV (0-100 μM; 3 hours) effectively and specifically inhibits DUSP14-mediated JNK dephosphorylation.[1]

Chemical Properties

Molecular Weight	608.62
Formula	C₂₆H₂₆F₆N₂O₄S₂
Cas No.	329317-98-8
Smiles	C(C)(C)(C1=CC=C(C(C)(C)C2=CC=C(NS(C(F)(F)F)(=O)=O)C=C2)C=C1)C3=CC=C(NS(C(F)(F)F)(=O)=O)C=C3
Relative Density.	1.416 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (369.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6431 mL	8.2153 mL	16.4306 mL	82.1531 mL
5 mM	0.3286 mL	1.6431 mL	3.2861 mL	16.4306 mL
10 mM	0.1643 mL	0.8215 mL	1.6431 mL	8.2153 mL
20 mM	0.0822 mL	0.4108 mL	0.8215 mL	4.1077 mL
50 mM	0.0329 mL	0.1643 mL	0.3286 mL	1.6431 mL
100 mM	0.0164 mL	0.0822 mL	0.1643 mL	0.8215 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc