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GSK-3β inhibitor 3

Name: GSK-3β inhibitor 3
Brand: TargetMol
SKU: T35554
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35554Cas No. 1448990-73-5

GSK-3β inhibitor 3 is a potent, selective, and irreversible covalent inhibitor of glycogen synthase kinase 3β (GSK-3β) with an IC50 of 6.6 μM, and can be used to study acute promyelocytic leukemia.

GSK-3β inhibitor 3

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Purity: 97.53%

Catalog No. T35554Cas No. 1448990-73-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$50	In Stock	In Stock
5 mg	$119	In Stock	In Stock
10 mg	$178	In Stock	In Stock
25 mg	$335	In Stock	In Stock
50 mg	$502	In Stock	In Stock
100 mg	$738	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$136	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.53%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	GSK-3β inhibitor 3 is a potent, selective, and irreversible covalent inhibitor of glycogen synthase kinase 3β (GSK-3β) with an IC50 of 6.6 μM, and can be used to study acute promyelocytic leukemia.
Targets&IC50	GSK-3β:6.6 μM (IC50)
In vitro	GSK-3β inhibitor 3 (compound 4-3) (6.25-100 μM; 24-48 h) dose-dependently inhibits cell viability, with IC50s of 19.56 μM and 26.42 μM in NB4 and NB4-R1 cells at 24 h, respectively. It (12.5-100 μM; 24 h) also significantly increases apoptosis in a dose-dependent manner in NB4 and NB4-R1 cells. Additionally, GSK-3β inhibitor 3 (100 μM) inhibits GSK-3α activity by 87.3%.[1]
In vivo	GSK-3β inhibitor 3 (compound 4-3) (15 mg/kg; a single i.p.; Balb/c female nude mice) demonstrates a T1/2 of 14.2 hours, an AUClast of 3503.42 ng/mL•h, and a Cmax of 515 ng/mL in mice.[1] Additionally, GSK-3β inhibitor 3 (15 mg/kg/d; i.p. for 2 weeks; Balb/c female nude mice) inhibits tumor growth by 75.97% compared to the vehicle control.[1]

Chemical Properties

Molecular Weight	327.37
Formula	C₁₈H₁₄FNO₂S
Cas No.	1448990-73-5
Smiles	Fc1ccc(cc1)C1CC(=O)N(C(=O)C=C)c2ccccc2S1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (687.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0546 mL	15.2732 mL	30.5465 mL	152.7324 mL
5 mM	0.6109 mL	3.0546 mL	6.1093 mL	30.5465 mL
10 mM	0.3055 mL	1.5273 mL	3.0546 mL	15.2732 mL
20 mM	0.1527 mL	0.7637 mL	1.5273 mL	7.6366 mL
50 mM	0.0611 mL	0.3055 mL	0.6109 mL	3.0546 mL
100 mM	0.0305 mL	0.1527 mL	0.3055 mL	1.5273 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc