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Anti-Phospho-ATM (S1981) Antibody (4B419)
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Catalog No. TMAC-00328
Alias p-ATM (Ser1981), p-ATM (S1981), ATM (p-Ser1981), ATM (p-S1981)
Anti-Phospho-ATM (S1981) Antibody (4B419) is a Rabbit antibody targeting Phospho-ATM (S1981). Anti-Phospho-ATM (S1981) Antibody (4B419) can be used in WB,ICC/IF,IHC,IP.
Anti-Phospho-ATM (S1981) Antibody (4B419)
Anti-Phospho-ATM (S1981) Antibody (4B419)
😃Good
Catalog No. TMAC-00328Alias p-ATM (Ser1981), p-ATM (S1981), ATM (p-Ser1981), ATM (p-S1981)
Anti-Phospho-ATM (S1981) Antibody (4B419) is a Rabbit antibody targeting Phospho-ATM (S1981). Anti-Phospho-ATM (S1981) Antibody (4B419) can be used in WB,ICC/IF,IHC,IP.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $298 | 7-10 days | |
| 100 μL | $496 | 7-10 days |
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| Description | Anti-Phospho-ATM (S1981) Antibody (4B419) is a Rabbit antibody targeting Phospho-ATM (S1981). Anti-Phospho-ATM (S1981) Antibody (4B419) can be used in WB,ICC/IF,IHC,IP. |
| Alias | p-ATM (Ser1981), p-ATM (S1981), ATM (p-Ser1981), ATM (p-S1981) |
| Ig Type | IgG |
| Reactivity | Human,Mouse |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC: 1:50-100; ICC/IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Serine / threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thus acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST] -Q. Phosphorylates 'Ser-139' of histone variant H2AX / H2AFX at double strand breaks (DSBs), recover equilibrium DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain Allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin , Soaccessability to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as A genre of activation of ABL1 and SAPK. May play a role in vesicle and / or protein transport. Could play A role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Ser1981 of human ATM |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 351 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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