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Anti-IL-5 Antibody
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Catalog No. T9901A-1408
Anti-IL-5 Antibody (e.g., Mepolizumab) is a humanized monoclonal antibody that specifically neutralizes interleukin-5 (IL-5), effectively disrupting the signaling for eosinophil activation and survival by blocking the ligand-receptor interaction. In allergic inflammation models, this antibody significantly diminishes tissue eosinophil infiltration and alleviates airway hyperresponsiveness.
Anti-IL-5 Antibody
Anti-IL-5 Antibody
Copy Product Info🥰Excellent
Catalog No. T9901A-1408
Anti-IL-5 Antibody (e.g., Mepolizumab) is a humanized monoclonal antibody that specifically neutralizes interleukin-5 (IL-5), effectively disrupting the signaling for eosinophil activation and survival by blocking the ligand-receptor interaction. In allergic inflammation models, this antibody significantly diminishes tissue eosinophil infiltration and alleviates airway hyperresponsiveness.
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| Description | Anti-IL-5 Antibody (e.g., Mepolizumab) is a humanized monoclonal antibody that specifically neutralizes interleukin-5 (IL-5), effectively disrupting the signaling for eosinophil activation and survival by blocking the ligand-receptor interaction. In allergic inflammation models, this antibody significantly diminishes tissue eosinophil infiltration and alleviates airway hyperresponsiveness. |
| In vivo | In eosinophilic asthma models, Anti-IL-5 Antibody significantly reduce eosinophil counts in sputum and blood. However, in severe asthma with anti-IL-5 IgG autoantibodies, the drug may be sequestered within the airways, preventing adequate neutralization of local IL-5 and leading to persistent eosinophilia [2]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | IL-5 |
| Isotype | IgG4 (S228P) |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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