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Anti-OTUD5/DUBA Polyclonal Antibody

Catalog No. TMAB-09833 Copy Product Info
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Anti-OTUD5/DUBA Polyclonal Antibody is a Rabbit antibody targeting OTUD5/DUBA. Anti-OTUD5/DUBA Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-OTUD5/DUBA Polyclonal Antibody

Copy Product Info
🥰Excellent
Catalog No. TMAB-09833

Anti-OTUD5/DUBA Polyclonal Antibody is a Rabbit antibody targeting OTUD5/DUBA. Anti-OTUD5/DUBA Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-OTUD5/DUBA Polyclonal Antibody
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2207-10 days7-10 days
100 μL$3717-10 days7-10 days
200 μL$5277-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-OTUD5/DUBA Polyclonal Antibody is a Rabbit antibody targeting OTUD5/DUBA. Anti-OTUD5/DUBA Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat,Chicken,Rabbit)
Verified Activity
Tissue/cell: human cervical cancer; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer (0.01 M, pH 6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37℃ for 20 min;
Incubation: Anti-OTUD5 Polyclonal Antibody, Unconjugated (TMAB-09833) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining
Application
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Tissue SpecificityExpressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThis gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human OTUD5/DUBA
Antigen Species
Human
Gene Name
OTUD5
Gene ID
Protein Name
OTU domain-containing protein 5
Uniprot ID
Function
Negative regulator of innate immune system. Has deubiquitinating activity that is directed towards 'Lys-63'-linked polyubiquitin chains. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production.
Chemical Properties
Molecular WeightTheoretical: 61 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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