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3-Bromopyruvic acid

Name: 3-Bromopyruvic acid
Brand: TargetMol
SKU: T5882
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5882Cas No. 1113-59-3

Alias Hexokinase II Inhibitor II, 3-BP, Bromopyruvic acid

3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.

3-Bromopyruvic acid

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Purity: 99.64%

Catalog No. T5882Alias Hexokinase II Inhibitor II, 3-BP, Bromopyruvic acidCas No. 1113-59-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$41	In Stock	In Stock
1 g	$48	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.64%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

3-Bromopyruvic acid AI Summary

3-Bromopyruvic acid exhibits a range of inhibitory activities across several biological targets. It is a reversible inhibitor of Escherichia coli dihydrodipicolinate synthase, demonstrating inhibition with a Ki value of 160,000 nM. The compound also inhibits the Mycobacterium tuberculosis ICL1 enzyme with an IC50 value of 17,500 nM and shows a binding affinity with a melting temperature of 52.5 degrees Celsius. Additionally, 3-Bromopyruvic acid shows antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in VERO-6 and Caco-2 cells, with inhibition rates of -0.01% and 10.28% at 10 µM, respectively, and exhibits an IC50 value greater than 20,000 nM. It also inhibits the SARS-CoV-2 3CL-Pro protease, with an inhibition rate of 41.31% at 20 µM. Furthermore, the compound reduces human HDAC6 activity by 12.68% and 5.09% using different peptide substrates. It has notable activity against bacterial enzymes, including NDM-1 (IC50: 2570 nM, Ki: 3800 nM), VIM-2 (IC50: 18,700 nM), IMP-1 (IC50: 28,900 nM), ImiS, and L1 (both IC50 > 40,000 nM)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.
Targets&IC50	Hexokinase II:2.4 mM (Ki)
Synonyms	Hexokinase II Inhibitor II, 3-BP, Bromopyruvic acid

Chemical Properties

Molecular Weight	166.96
Formula	C₃H₃BrO₃
Cas No.	1113-59-3
Smiles	OC(=O)C(=O)CBr
Relative Density.	2.011 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 122.5 mg/mL (733.71 mM)

H2O: 32 mg/mL (191.66 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.9895 mL	29.9473 mL	59.8946 mL	299.4729 mL
5 mM	1.1979 mL	5.9895 mL	11.9789 mL	59.8946 mL
10 mM	0.5989 mL	2.9947 mL	5.9895 mL	29.9473 mL
20 mM	0.2995 mL	1.4974 mL	2.9947 mL	14.9736 mL
50 mM	0.1198 mL	0.5989 mL	1.1979 mL	5.9895 mL
100 mM	0.0599 mL	0.2995 mL	0.5989 mL	2.9947 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc