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Anti-Pepsinogen C/PGC Antibody (4C341)
😃Good
Catalog No. TMAY-02220
Alias progastricsin (pepsinogen C)
Anti-Pepsinogen C/PGC Antibody (4C341) is a Mouse antibody targeting Pepsinogen C/PGC. Anti-Pepsinogen C/PGC Antibody (4C341) can be used in ELISA,IHC-P.
Anti-Pepsinogen C/PGC Antibody (4C341)
Anti-Pepsinogen C/PGC Antibody (4C341)
😃Good
Catalog No. TMAY-02220Alias progastricsin (pepsinogen C)
Anti-Pepsinogen C/PGC Antibody (4C341) is a Mouse antibody targeting Pepsinogen C/PGC. Anti-Pepsinogen C/PGC Antibody (4C341) can be used in ELISA,IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $293 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA, IHC-P Reactivity: Human |
| Alias | progastricsin (pepsinogen C) |
| Ig Type | Mouse IgG1 |
| Clone | 4C341 |
| Reactivity | Human |
| Verified Activity | Immunochemical staining of human PGC in human stomach (from 3 donors) with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| Application | ELISA,IHC-P |
| Recommended Dose | ELISA: 1:1000-1:2000; IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Pepsinogen C / PGC (rh Pepsinogen C / PGC; TMPY-01731; NP_002621.1; Met 1-Ala 388). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Pepsinogen C, also known as PGC, is an aspartic proteinase that belongs to the peptidase family A1. Pepsinogen C is synthesized in the gastric mucosa as inactive precursors, known as zymogens. Pepsinogen C contains a prosegment that serves to stabilize the inactive form and prevent entry of the substrate to the active site. At low PH conditions, Pepsinogen C undergoes conversion into active enzyme. Pepsinogen C has been found expressed in all regions of the stomach mucosa and also in the proximal duodenal mucosa. In stomach cancer tissues and cancer cell lines, the expressions of the pepsinogen genes were decreased or lost, in good accordance with their pepsinogen productions. No gross structural changes of the pepsinogen genes were observed in these cancers, but the methylation patterns of the pepsinogen genes were found to be altered in different ways in different cancers. Serum levels of Pepsinogen C are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Pepsinogen C / PGC protein (TMPY-01731) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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