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Anti-Acetyl-p53 (Lys370) Antibody (8D75)
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Catalog No. TMAC-02993
Alias p53K370-acetylated, p53K370ac, Ac-p53K370, Ac-p53 (Lys370), Ac-p53 (K370), Acetyl-p53 (K370)
Anti-Acetyl-p53 (Lys370) Antibody (8D75) is a Rabbit antibody targeting Acetyl-p53 (Lys370). Anti-Acetyl-p53 (Lys370) Antibody (8D75) can be used in ICC/IF,IP,WB.
Anti-Acetyl-p53 (Lys370) Antibody (8D75)
Anti-Acetyl-p53 (Lys370) Antibody (8D75)
😃Good
Catalog No. TMAC-02993Alias p53K370-acetylated, p53K370ac, Ac-p53K370, Ac-p53 (Lys370), Ac-p53 (K370), Acetyl-p53 (K370)
Anti-Acetyl-p53 (Lys370) Antibody (8D75) is a Rabbit antibody targeting Acetyl-p53 (Lys370). Anti-Acetyl-p53 (Lys370) Antibody (8D75) can be used in ICC/IF,IP,WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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Chemical Properties
| Description | Anti-Acetyl-p53 (Lys370) Antibody (8D75) is a Rabbit antibody targeting Acetyl-p53 (Lys370). Anti-Acetyl-p53 (Lys370) Antibody (8D75) can be used in ICC/IF,IP,WB. |
| Synonyms | p53K370-acetylated, p53K370ac, Ac-p53K370, Ac-p53 (Lys370), Ac-p53 (K370), Acetyl-p53 (K370) |
| Ig Type | IgG |
| Clone | 8D75 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. HW221. 2. HW221. 3. HW221. |
| Application | |
| Recommended Dose | WB: 1:1000-2000; ICC/IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers. |
| Conjucates | Unconjugated |
| Others Formats | Methylated/Acetylated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 53 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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