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GLPG0634 analog
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Catalog No. T3076Cas No. 1206101-20-3
Alias GLPG0634 analogue
GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.
GLPG0634 analog
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Purity: 99.64%
Catalog No. T3076Alias GLPG0634 analogueCas No. 1206101-20-3
GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $34 | In Stock | In Stock | |
| 2 mg | $48 | In Stock | In Stock | |
| 5 mg | $80 | In Stock | In Stock | |
| 10 mg | $147 | In Stock | In Stock | |
| 25 mg | $277 | In Stock | In Stock | |
| 50 mg | $490 | In Stock | In Stock | |
| 100 mg | $693 | In Stock | In Stock | |
| 500 mg | $1,450 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $89 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.64%
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively. |
| Targets&IC50 | JAK3:810nM, JAK2:28nM, JAK1:10nM, TYK2:116 nM |
| In vitro | In multiple cell lines, GLPG0634 inhibited IFN-αB2-induced JAK1/TYK2 type II receptor signaling and IL-2/4-induced JAK1/JAK3/γc signaling (IC50: 150-760 nM). At the cellular level, GLPG0634 was more selective for JAK1-containing JAK/STAT signaling than JAK2 kinase. In addition, GLPG0634 inhibited the proliferation of Th1/Th2/Th17 cells. |
| In vivo | In multiple cell lines, GLPG0634 inhibited IFN-αB2-induced JAK1/TYK2 type II receptor signaling and IL-2/4-induced JAK1/JAK3/γc signaling (IC50: 150-760 nM). At the cellular level, GLPG0634 was more selective for JAK1-containing JAK/STAT signaling than JAK2 kinase. In addition, GLPG0634 inhibited the proliferation of Th1/Th2/Th17 cells. |
| Kinase Assay | EC50 values of the test compounds are calculated from serial dilution series ranging from 200 to 0.1 μM. Cells are seeded in 96-well plates at a density of 5,000 cells per well in 100 μL medium. The next day, 100 μL medium containing each test compound is added. Cells are incubated for 16 h, fixed and processed for automated microscopy. EC50 estimates are calculated using four-parameter log-logistic fit with the package drc[1]. |
| Synonyms | GLPG0634 analogue |
| Molecular Weight | 410.43 |
| Formula | C23H18N6O2 |
| Cas No. | 1206101-20-3 |
| Smiles | O=C(Nc1nc2cccc(-c3ccc(OCc4ccc(nc4)C#N)cc3)n2n1)C1CC1 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 7.5 mg/mL (18.27 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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