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Topilutamide

Name: Topilutamide
Brand: TargetMol
SKU: T13184
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13184Cas No. 260980-89-0

Alias Fluridil, BP766

Topilutamide (Fluridil) is a topical nonsteroidal antiandrogen.

Topilutamide

🥰Excellent

Purity: 99.24%

Catalog No. T13184Alias Fluridil, BP766Cas No. 260980-89-0

Topilutamide (Fluridil) is a topical nonsteroidal antiandrogen.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$413	In Stock	In Stock
50 mg	$648	In Stock	In Stock
100 mg	$923	In Stock	In Stock
200 mg	$1,260	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.24%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Topilutamide (Fluridil) is a topical nonsteroidal antiandrogen.
In vivo	One of the commonly used approaches to treat metastatic prostate cancer is via first-generation nonsteroidal anti-androgens (NSAAs), namely Flutamide, Nilutamide, Bicalutamide and Topilutamide[1].
Synonyms	Fluridil, BP766

Chemical Properties

Molecular Weight	403.23
Formula	C₁₃H₁₁F₆N₃O₅
Cas No.	260980-89-0
Smiles	CC(O)(CNC(=O)C(F)(F)F)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O
Relative Density.	1.588 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 255 mg/mL (632.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4800 mL	12.3999 mL	24.7997 mL	123.9987 mL
5 mM	0.4960 mL	2.4800 mL	4.9599 mL	24.7997 mL
10 mM	0.2480 mL	1.2400 mL	2.4800 mL	12.3999 mL
20 mM	0.1240 mL	0.6200 mL	1.2400 mL	6.1999 mL
50 mM	0.0496 mL	0.2480 mL	0.4960 mL	2.4800 mL
100 mM	0.0248 mL	0.1240 mL	0.2480 mL	1.2400 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc