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TargetMol | Compound Library

Pyroptosis Compound Library

Catalog No. L8720

Pyroptosis, also known as cellular inflammatory necrosis, is a programmed necrosis; it is manifested by the continuous distention of cells until the cell membrane ruptures, leading to the release of cellular contents and thus activating a strong inflammatory response. According to the activation mechanism, it can be divided into caspase-1-dependent classical pathway and caspase-1-independent (caspase-4/5/11) non-classical pathway. caspase-1 and caspase-4/5/11 cleaves the Gasdermin-D (GSDMD) protein and release its N-terminal structural domain, which binds membrane lipids and perforates the cell membrane, leading to distension by changes in cellular osmotic pressure until the cell membrane ruptures. Both pathways simultaneously induce cleavage of IL-1β and IL-18 precursors to form mature IL-1β and IL-18, which are released into the extracellular space and cause an inflammatory response. Studying the mechanism of Pyroptosis helps researchers to understand its role and development in related diseases such as infectious diseases, neurological diseases, cardiovascular diseases, cancer and other diseases. The TargetMol Pyroptosis Compound Library is a collection of 1066 pyroptosis-related compounds that can be used in relevant studies.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L8720

Pyroptosis Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • 1066 types of active small molecules associated with pyroptosis for high-throughput and high-content screening.
  • Targets include Caspase-1, Caspase-4, Caspase-5, Caspase-11, NLRP3, gasdermin D, etc.
  • Some compounds have been FDA-approved.
  • Detailed specifications, compound structures, target information, activity descriptions, etc.
  • Various detection techniques such as NMR, HPLC/LCMS to ensure the correct structure and high purity of the product and reduce false positives.

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

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Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

NF-κB
Apoptosis
Autophagy
Reactive Oxygen Species
COX
p38 MAPK
mTOR
Caspase
AMPK
TNF
IL Receptor
Endogenous Metabolite
Antibacterial
TLR
PI3K
ROS
JNK
IκB/IKK
p53
Akt
ERK
NOD
HIV Protease
RIP kinase
Interleukin
NO Synthase
Ferroptosis
Antioxidant
E1/E2/E3 Enzyme
Mdm2
Antifungal
PPAR
Parasite
STAT
Cytochromes P450
DNA-PK
Bcl-2 Family
IRAK
Antibiotic
NOS
Mitophagy
PARP
Influenza Virus
Calcium Channel
Mitochondrial Metabolism
NOD-like Receptor (NLR)
MMP
Lipoxygenase
CDK
DNA/RNA Synthesis
MAPK
SARS-CoV
Nrf2
ROS Kinase
Virus Protease
JAK
Potassium Channel
Dehydrogenase
Topoisomerase
EGFR
Sirtuin
Beta Amyloid
VEGFR
PKC
Cholinesterase (ChE)
ASK
ATM/ATR
GABA Receptor
S6 Kinase
Tyrosinase
HIF/HIF Prolyl-Hydroxylase
Proteasome
Estrogen/progestogen Receptor
Wnt/beta-catenin
IAP
HSV
TGF-beta/Smad
PGE Synthase
Prostaglandin Receptor
ALK
HDAC
5-HT Receptor
AChR
c-Met/HGFR
HBV
PDE
Xanthine Oxidase
P-gp
HSP
Pyroptosis
Casein Kinase
MEK
Anti-infection
Sodium Channel
Src
Adenosine Receptor
NADPH
PKA
TRP/TRPV Channel
Glucocorticoid Receptor
Aurora Kinase
Trk receptor
Free radical scavengers
transporter
Ligand for E3 Ligase
PDK
FLT
ATPase
Chloride channel
Carbonic Anhydrase
HCV Protease
RAAS
Histamine Receptor
Glutathione Peroxidase
GSK-3
Serine Protease
Leukotriene Receptor
Aryl Hydrocarbon Receptor
MAO
Immunology/Inflammation related
Raf
Molecular Glues
Opioid Receptor
IGF-1R
Antiviral
Reverse Transcriptase
FGFR
Microtubule Associated
Transferase
Integrin
DNA Alkylator/Crosslinker
Reductase
BACE
IFNAR
PERK
Tie-2
Phosphatase
MRP
Estrogen Receptor/ERR
Tyrosine Kinases
RANKL/RANK
Bcr-Abl
Antifection
Epigenetic Reader Domain
CaMK
DNA
DUB
AIM2
Retinoid Receptor
c-Fms
Aromatase
Phospholipase
HIF
Cannabinoid Receptor
Complement System
Syk
c-Kit
FAK
MLK
ADC Cytotoxin
FOXO3
PROTACs
NPC1L1
RAR/RXR
ROR
Dynamin
MyD88
LTR
Na+/Ca2+ Exchanger
Lipase
gp120/CD4
Progesterone Receptor
OCT
c-Myc
Rho
Serine/threonin kinase
Liver X Receptor
Nucleoside Antimetabolite/Analog
Cysteine Protease
FXR
Glucokinase
ROCK
Adrenergic Receptor
Amylase
iGluR
SIK
Annexin A
FLAP
UGT
PAFR
Haspin Kinase
LDL
Gamma-secretase
Drug Metabolite
Glucagon Receptor
NMDAR
Glucosidase
PAK
PDGFR
Hedgehog/Smoothened
FAAH
CCR
CXCR
PTEN
Somatostatin
Chk
PAD
cAMP
Indoleamine 2,3-Dioxygenase (IDO)
Androgen Receptor
SGLT
ATP Citrate Lyase
OXPHOS
Beta-Secretase
Glutathione reductase
STING
LRRK2
Aminopeptidase
cGAS
PAI-1
RSV
GST
PI4K
Adenosine Deaminase
c-RET
Discoidin Domain Receptor (DDR)
Gap Junction Protein
Platelet aggregation
NADPH-oxidase
AhR
CFTR
PKM
S1P Receptor
HER
Monoamine Oxidase
BTK

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