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TargetMol | Compound Library

Pyroptosis Compound Library

Catalog No. L8720

Pyroptosis, also known as cellular inflammatory necrosis, is a programmed necrosis; it is manifested by the continuous distention of cells until the cell membrane ruptures, leading to the release of cellular contents and thus activating a strong inflammatory response. According to the activation mechanism, it can be divided into caspase-1-dependent classical pathway and caspase-1-independent (caspase-4/5/11) non-classical pathway. caspase-1 and caspase-4/5/11 cleaves the Gasdermin-D (GSDMD) protein and release its N-terminal structural domain, which binds membrane lipids and perforates the cell membrane, leading to distension by changes in cellular osmotic pressure until the cell membrane ruptures. Both pathways simultaneously induce cleavage of IL-1β and IL-18 precursors to form mature IL-1β and IL-18, which are released into the extracellular space and cause an inflammatory response. Studying the mechanism of Pyroptosis helps researchers to understand its role and development in related diseases such as infectious diseases, neurological diseases, cardiovascular diseases, cancer and other diseases. The TargetMol Pyroptosis Compound Library is a collection of 1066 pyroptosis-related compounds that can be used in relevant studies.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L8720

Pyroptosis Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • 1066 types of active small molecules associated with pyroptosis for high-throughput and high-content screening.
  • Targets include Caspase-1, Caspase-4, Caspase-5, Caspase-11, NLRP3, gasdermin D, etc.
  • Some compounds have been FDA-approved.
  • Detailed specifications, compound structures, target information, activity descriptions, etc.
  • Various detection techniques such as NMR, HPLC/LCMS to ensure the correct structure and high purity of the product and reduce false positives.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Apoptosis
NF-κB
Autophagy
Reactive Oxygen Species
COX
Endogenous Metabolite
p38 MAPK
mTOR
Caspase
AMPK
TNF
IL Receptor
Antibacterial
PI3K
TLR
MDM-2/p53
ROS
JNK
IκB/IKK
Akt
p53
Interleukin
ERK
Parasite
NOD
NOD-like Receptor (NLR)
HIV Protease
NO Synthase
Antifungal
RIP kinase
Bcl-2 Family
Ferroptosis
Antioxidant
PPAR
E1/E2/E3 Enzyme
Cytochromes P450
Mdm2
STAT
Antibiotic
DNA-PK
Influenza Virus
IRAK
Mitophagy
PARP
Calcium Channel
MMP
NOS
Mitochondrial Metabolism
DNA/RNA Synthesis
MAPK
SARS-CoV
ROS Kinase
Lipoxygenase
Virus Protease
CDK
Nrf2
VEGFR
JAK
EGFR
GABA Receptor
Potassium Channel
HIF/HIF Prolyl-Hydroxylase
Dehydrogenase
Wnt/beta-catenin
Topoisomerase
HSV
Cholinesterase (ChE)
Sirtuin
Pyroptosis
Beta Amyloid
PKC
Prostaglandin Receptor
ASK
ATM/ATR
Anti-infection
S6 Kinase
Tyrosinase
Proteasome
Estrogen/progestogen Receptor
IAP
Drug Metabolite
Xanthine Oxidase
TGF-beta/Smad
PGE Synthase
P-gp
ALK
HDAC
5-HT Receptor
AChR
Sodium Channel
Src
c-Met/HGFR
Phosphatase
HBV
TRP/TRPV Channel
PDE
HSP
Casein Kinase
MEK
FLT
ATPase
HCV Protease
Adenosine Receptor
Reductase
NADPH
PKA
Estrogen Receptor/ERR
Serine Protease
Glucocorticoid Receptor
Molecular Glues
Aurora Kinase
OXPHOS
Trk receptor
Free radical scavengers
transporter
Ligand for E3 Ligase
PDK
Microtubule Associated
Chloride channel
Carbonic Anhydrase
IFNAR
RAAS
Histamine Receptor
Glutathione Peroxidase
GSK-3
Leukotriene Receptor
MAO
Aryl Hydrocarbon Receptor
Immunology/Inflammation related
Raf
Antifection
Opioid Receptor
PTEN
IGF-1R
CaMK
Antiviral
AIM2
Reverse Transcriptase
Phospholipase
FGFR
Complement System
Ras
Transferase
ADC Cytotoxin
Integrin
DNA Alkylator/Crosslinker
BACE
PERK
Tie-2
MRP
Tyrosine Kinases
Liver X Receptor
RANKL/RANK
Prolyl Endopeptidase (PREP)
UGT
Bcr-Abl
Gamma-secretase
Glucosidase
Stearoyl-CoA Desaturase (SCD)
Angiotensin-converting Enzyme (ACE)
Epigenetic Reader Domain
DNA
DUB
Androgen Receptor
SGLT
Beta-Secretase
Histone Acetyltransferase
FKBP
Retinoid Receptor
c-Fms
Aromatase
PI4K
HIF
c-RET
Cuproptosis
Cannabinoid Receptor
Syk
c-Kit
FAK
CFTR
MLK
IKZF
FOXO3
PROTACs
NPC1L1
RAR/RXR
CD38
ROR
Dynamin
MyD88
LTR
Na+/Ca2+ Exchanger
Lipase
Necroptosis
gp120/CD4
MIF
Progesterone Receptor
OCT
c-Myc
ASCT
Rho
Serine/threonin kinase
Nucleoside Antimetabolite/Analog
Cysteine Protease
FXR
Glucokinase
ROCK
Amylase
Adrenergic Receptor
IDO
iGluR
SIK
Annexin A
FLAP
PAFR
Haspin Kinase
LDL
Glucagon Receptor
NMDAR
Na-K-Cl cotransporter
Hedgehog/Smoothened
PDGFR
PAK
FAAH
CCR
CXCR
Somatostatin
Chk
PAD
cAMP
Indoleamine 2,3-Dioxygenase (IDO)
ATP Citrate Lyase
Lipid
Glutathione reductase
STING
LRRK2
Aminopeptidase
GPCR19
cGAS
PAI-1
RSV
GST
KRas
Adenosine Deaminase
Discoidin Domain Receptor (DDR)
Gap Junction Protein
Platelet aggregation
NADPH-oxidase
AhR
HER
PKM
S1P Receptor
Monoamine Oxidase
BTK

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